Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Effect of Types and Mixing Ratios of Water-Soluble Polymers on In Vitro Release Profile of Sold Dispersion for Acyclovir

아시클로비어 고체분산체의 용해도에 대한 수용성 고분자의 종류 및 배합 비율에 따른 효과

  • Ahn, Yong-San (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Lee, Ha-Young (Department of Advanced Organic Materials Engineering, Chonbuk National University) ;
  • Hong, Keum-Duck (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Jung, Sung-Beum (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Cho, Sun-Hang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Rhee, John M. (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Khang, Gil-Son (Department of Polymer.Nano Science and Technology, Chonbuk National University)
  • 안용산 (전북대학교 고분자.나노공학과) ;
  • 이하영 (전북대학교 유기신물질 공학과) ;
  • 홍금덕 (전북대학교 고분자.나노공학과) ;
  • 정성범 (전북대학교 고분자.나노공학과) ;
  • 조선행 (한국화학연구원 생체의료고분자팀) ;
  • 이종문 (전북대학교 고분자.나노공학과) ;
  • 이해방 (한국화학연구원 생체의료고분자팀) ;
  • 강길선 (전북대학교 고분자.나노공학과)
  • Published : 2004.08.20
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Abstract

Acyclovir (ACV) is one of the most effective and selective agents against viruses of the herpes group. Because of low solubility, bioavailability of ACV has shown below 30% with oral dosage form. In our previous study, we reported that the fabrication of solid dispersion of ACV was possible and the solid dispersion of ACV and PVP was the most useful in all samples. In this study, we examined the effect of mixture ratio of polymers (PEG and PVP) to ACV. Solubility of ACV was dramatically increased up to 25 mg/ml in $80^{\circ}C$ distilled water. So water was used as a solvent to eliminate problem of residual solvent. Spray drying method was used for the solid dispersion of ACV as solvent extraction. Different scanning calorimeter was used to check degradation of drug. Polymer carriers were PEG 6,000 and PVP. In summary, ACV-PVP (1:3) showed the best solubility in distilled water.

Keywords

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