Journal of Pharmaceutical Investigation

  • 제34권1호
  • /
  • Pages.35-42
  • /
  • 2004
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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자가미세유화를 이용한 이부프로펜 액상제제의 제조와 특성

Preparation and Characterization of Liquefied Ibuprofen Using Self-Microemulsion Drug Delivery System (SMEDDS)

  • 안용산 (전북대학교 고분자.나노공학과) ;
  • 송지희 (전북대학교 고분자.나노공학과) ;
  • 강복기 (전북대학교 고분자.나노공학과) ;
  • 김문석 (한국화학연구원 생체의료고분자팀) ;
  • 조선행 (한국화학연구원 생체의료고분자팀) ;
  • 이종문 (전북대학교 고분자.나노공학과) ;
  • 이해방 (한국화학연구원 생체의료고분자팀) ;
  • 강길선 (전북대학교 고분자.나노공학과)
  • Ahn, Yong-San (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Song, Ji-Hee (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Kang, Bok-Ki (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Kim, Moon-Suk (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Cho, Sun-Hang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Rhee, John-M. (Department of Polymer.Nano Science and Technology, Chonbuk National University) ;
  • Lee, Hai-Bang (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Khang, Gil-Son (Department of Polymer.Nano Science and Technology, Chonbuk National University)
  • 발행 : 2004.02.20
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초록

Ibuprofen (IBU), is a non-steroidal anti-inflammatory drug, used to treat rheumatoid arthritis, removal of fever and mild to moderate pain. Because of small dosage and very low accumulation in the body, IBU has been used to heal children's fever. However, IBU was very low solubility in a low pH and water (in water $0.03{\sim}2.5$ mg/ml). A nanoemulsion containing IBU by means of self-microemulsion drug delver system (SMEDDS) was prepared in order to enhance the solubility of IBU. The SMEDDS was composed of cosurfactant, oil and surfactant The solubility of IBU in various components such as cosurfactant, oil and surfactant was examined. $Carbitol^{\circledR}\;(386.99{\pm}20.5\;mg/ml)$ as a cosurfactant, $Labrafil^{\circledR}$　 M1944CS $(90.16{\pm}1.60mg/ml)$ as an oil and $Cremopher^{\circledR}$　 RH-40 $(239.01{\pm}2.8\;mg/ml)$ as a surfactant were used in this study for preparing SMEDDS. Optimized formulation of SMEDDS was obtained by phase diagram which express the section of nanoemulsion formation. The SMEDDS containing IBU had higher dissolution rate than conventional IBU sirups. Thus the SMEDDS was a potential candidate of stable conventional and effective oral dosage form for IBU.

키워드

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피인용 문헌

  1. Degradation Properties of Ibuprofen Using Photocatalytic Process vol.21, pp.4, 2012, https://doi.org/10.5322/JES.2012.21.4.411