생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
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뜸부기 추출물이 물질대사 조절에 미치는 영향

Effects of the Extracts from Pelvetia siliquosa on Metabolism Regulation in Rats

  • 이상현 (서울대학교 약학대학) ;
  • 이연실 ((주) 월드씨그린 석원생명과학연구소) ;
  • 정상훈 (한국과학기술연구원) ;
  • 신국현 ((주) 월드씨그린 석원생명과학연구소) ;
  • 김박광 (서울대학교 약학대학)
  • 발행 : 2004.09.30
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초록

Effects of the EtOH extract from Pelvetia siliquosa on $CCl_4$-induced hepatotoxicity as well as streptozotocin-induced diabetes in rats were investigated. The EtOH extract was found to cause an inhibition of the rise in the transaminase activities in $CCl_4$-intoxicated rats. Also, the EtOH extract exhibited a rat lens aldose reductase inhibition in vitro and showed an inhibition of not only glucose concentrations but also sorbitol accumulations in the lenses, red blood cells and sciatic nerves in the STZ-induced diabetic rats in vivo. These results suggested that this plant might possess hepatoprotective and anti-diabetic activities.

키워드

참고문헌

  1. Yoon, J. T. (1995) Developmental morphology on the regeneration of Pelvetia siliquosa Tseng et Chang, Phaeophyta in Korea. Chungbuk National University. Ph. D. Thesis
  2. Oh, Y S., Lee, I. K, and Boo, S. M. (1990) An annotated account of Korean economic seaweeds for food, medicinal and industrial uses. Kor. J. Phycol. 5: 57-71
  3. Lee, Y and Kang, S. A (2001) Catalogue of the Seaweeds in Korea. Jeju Natural University Press. pp. 179-180
  4. 공용근, 김길주, 윤장택(1998) 남해안 지역특성 해조류 양식품종 및 기술배갈 II. 뜸부기 양식기술 개발 시험, 남해수산연구소 사업보고서: pp. 242-254
  5. 한국식물도감 제8권 식물편(해조류) (1968) 문교부. p. 29
  6. Seaquist, E. R, Goeta, E. C., Rich, S., and Barbosa. (1989) Familial clustering of diabetic kidney disease: Evidence for genetic susceptibility to diabetic nephropathy. N. Eng. J. Med. 320: 1161-65 https://doi.org/10.1056/NEJM198905043201801
  7. Sato, Y. and Rifkin, D. B. (1989) Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transformation growth factor Bl-like molecule by plasmin during coculture. J. Cell. Biol. 109: 309-315 https://doi.org/10.1083/jcb.109.1.309
  8. Williamson, J. R, Chang, K, Frangos, M., Hasan, K. S., Ido, Y, Kawamura, T., Nyengard, J. R., Van Den Enden M., Kilo C., and Tilton R. G. (1993) Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42: 801-813 https://doi.org/10.2337/diabetes.42.6.801
  9. Greene, D. A, Lattimer, S. A, and Sima, A . F. (1987) Sorbitol, phosphinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N. Eng. J. Med. 316: 599-606 https://doi.org/10.1056/NEJM198703053161007
  10. Malone, J. I., Knox, G., Benford, S., and Tedesco, T. A (1980) Red cell sorbitol. An Indicator of diabetic control. Diabetes 29: 861 https://doi.org/10.2337/diabetes.29.11.861
  11. Gabby, K. H. (1972) Purification and immunological identification of bovine retinal aldose reductase. Isr. J. Med. Sci. 8: 1626
  12. Travis, S. F, Morrison, A. D., Clements, R. S. Jr., Winegrad, A I., and Oski, E. A. (1974) The role of the polyol pathway in metahemoglobin reduction in human red cells. Br. J. Haematol. 27: 597 https://doi.org/10.1111/j.1365-2141.1974.tb06625.x
  13. Beyer, M. A. and Farnsworth, P. N. (1979) Diminished sugar cataractogenesis by quercetin. Exp. Eye Res. 28: 709 https://doi.org/10.1016/0014-4835(79)90071-X
  14. Parmar, N. S., and Ghosh, M. N. (1979) Effect of gossypin, a flavonoid, on the formation of galactose induced cataracts in rats. Exp. Eye Res. 29: 229 https://doi.org/10.1016/0014-4835(79)90003-4
  15. Datiles, M., and Fukui, M. N. (1982) Galactose cataract prevention with sorbinil, an aldose reductase inhibitor. Invest. Opthalmol. Vis. Sci. 22: 174
  16. Sestani, K., and Bellini, F. (1984) N-[(5-(trifluoromethyl)-6methoxy- l-naphthalenyl)thioxomethyl]-N-methyl-glycine, a potent, orally active aldose reductase inhibitor. J. Med. Chem. 27: 255 https://doi.org/10.1021/jm00369a003
  17. Hayman, S. and Kinoshita, J. H. (1965) Isolation and properties of lens aldose reductase. J. BioI. Chem. 240: 877-882
  18. Clements, R. S., Jr. Morrison, A. D., and Winegard, A. I. (1969) Polyol pathway in aorta: Regulation by hormones. Science 166: 1007-1008 https://doi.org/10.1126/science.166.3908.1007