Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of the Extracts from Pelvetia siliquosa on Metabolism Regulation in Rats

뜸부기 추출물이 물질대사 조절에 미치는 영향

  • 이상현 (서울대학교 약학대학) ;
  • 이연실 ((주) 월드씨그린 석원생명과학연구소) ;
  • 정상훈 (한국과학기술연구원) ;
  • 신국현 ((주) 월드씨그린 석원생명과학연구소) ;
  • 김박광 (서울대학교 약학대학)
  • Published : 2004.09.30
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Abstract

Effects of the EtOH extract from Pelvetia siliquosa on $CCl_4$-induced hepatotoxicity as well as streptozotocin-induced diabetes in rats were investigated. The EtOH extract was found to cause an inhibition of the rise in the transaminase activities in $CCl_4$-intoxicated rats. Also, the EtOH extract exhibited a rat lens aldose reductase inhibition in vitro and showed an inhibition of not only glucose concentrations but also sorbitol accumulations in the lenses, red blood cells and sciatic nerves in the STZ-induced diabetic rats in vivo. These results suggested that this plant might possess hepatoprotective and anti-diabetic activities.

Keywords

References

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