Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Stilbene Derivatives from Rheum undulatum on Carrageenan-Induced Acute Edema in Rats

Carrageenan 유발 족부종에 미치는 종대황 스틸벤 유도체의 효과

  • 고성권 (중앙대학교 인삼산업연구센터) ;
  • 신차균 (중앙대학교 생명공학과) ;
  • 이학성 (중앙대학교 생명공학과) ;
  • 한성태 (중앙대학교 생명공학과) ;
  • 양병욱 (중앙대학교 생명공학과) ;
  • 임병옥 (중앙대학교 인삼산업연구센터) ;
  • 정성현 (경희대학교 약학대학)
  • Published : 2004.06.30
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Abstract

In order to examine the anti-ohyul (anti-inflammatory) activity of rhubarb, we investigated the effects of stilbene derivatives obtained from rhizomes of Rheum undulatum on the carrageenan-induced hind paw edema in rats. Administration of stilbene aglycon (rhapontigenin) at doses of 50 and 100 mg/kg exhibited the anti- edema effect in dose dependent manner and stilbene glycosides $(rhaponticin,\;piceatannol-3'-O-{\beta}-D-glucopyranoside)$ at a dose of 100 mg/kg also showed inhibitory effect on the carrageenan-induced edema. These inhibitory effects may ascribed, at least in part, to the anti-ohyul activity of rhubarb.

Keywords

References

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