Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemical Constituents and Biological Activities of Cichorium intybus L.

  • El-Lakany, Abdalla M. (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria) ;
  • Aboul-Ela, Maha A. (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria) ;
  • Abdul-Ghani, Mohamed M. (Department of Organic Chemistry, Faculty of Science, Beirut Arab University) ;
  • Mekky, Hattem (Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria)
  • Published : 2004.04.30
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Abstract

Continuation of a phytochemical study of Cichorium intybus L. (Astraceae) growing in Egypt, resulted in the isolation and identification of a new sesquiterpene lactone 3,4-dihydrolactucin, in addition to the eight known compounds; kaempferol, isoscutellarin, cichoriin, umbelliferone, lupeol, lupeol acetate, ${\beta}-sitosterol$, and ${\beta}-sitosterol-3-O-glucoside$. Chemical structures of the isolated compounds were assigned based on different physical, chemical, and spectroscopic techniques including IR, UV, MS, 1D- and 2D-NMR spectra. Furthermore, the antimicrobial, and spasmogenic activities of some fractions and isolates were also assessed.

Keywords

References

  1. Abdel Salam, N. A., Mahmoud, Z. F. and Kassem, F. K., Sesquiterpene lactones, coumarins and flavonoids of Launaea tenuiloba Boiss. grown in Egypt. Egypt. J. Pharm. Sci., 27(1), 275-282 (1986)
  2. Aboul-Ela, M. A., Abdul-Ghani, M. M., El-Fikky, F. K., Lakany, A. M. and Ghazy, N. M., Chemical constituents of Cirisum Syriacum and Chichorium intybus (Asteraceae) Growing in Egypt. Alex. J. Pharm. Sci., 16(2), 152-156 (2002) https://doi.org/10.1002/jps.3080160216
  3. Amer, M. M. A., Ph.D. Thesis, The Pharmacognostical Study and Phytochemical Investigation of Certain Plants Belonging to Family Compositae, Pharmacognosy Department, Faculty of Pharmacy, University of Alexandria, Egypt (1974)
  4. Berry, W. L. M., Pharmacological experiments on isolated organ preparations, 2$^{nd}$ ed., E. and S. Livingstone, Edinburgh and London (1970)
  5. Crellin, J. K. and Philpatt, J.; A Reference Guide to Medicinal Plants, Herbal Medicine Past and Present, Duke University Press, Durham and London (1990)
  6. Fetrow, C. W. and Avila, J. R., Professional Handbook of complementary medicines, Spring House Corporation (1999)
  7. Hertog, M. G. L., Hollman, P. C. H. and Kotan, M. B., Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem, 40, 2379- 2383 (1992) https://doi.org/10.1021/jf00024a011
  8. Hertog, M. G. L., Hollman, P.C.H. and Venema. D. P., Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoids in vegetables and fruits. J. Agric. Food Chem, 40, 1591-1598 (1992) https://doi.org/10.1021/jf00021a023
  9. Jay, M. and Gonnet, J. F., Isoscutellareine isolee de Pinguicula vulgaris. Phytochemistry, 12, 953-954 (1973) https://doi.org/10.1016/0031-9422(73)80718-6
  10. Jian, S. R. and Kar, A., The antibacterial activity of some essential oils and their combinations, Planta Med., 20(2), 118-122 (1971) https://doi.org/10.1055/s-0028-1099675
  11. Khalil, A. T., Abd-El-Fattah, H. and Mansour, E. S., Guaianolides from Lactuca saligna, Planta Med., 57, 190-191 (1991) https://doi.org/10.1055/s-2006-960064
  12. Kisiel, W.; Brszez, B. and Szneler, E., Sesquiterpene lactones from Lactuca tatarica, Phytochemistry, 45(2), 365-368 (1997) https://doi.org/10.1016/S0031-9422(96)00820-5
  13. Markham, K. R., Ternal, B., Stanly, R., Geiger, H. and Mabry, T.J., Carbon 13 NMR studies of flavonoids III. Naturally occurring flavonoid glycosides and their acetylated derivatives, Tetrahedron, 34, 1389-1397 (1978) https://doi.org/10.1016/0040-4020(78)88336-7
  14. El-Masry, S., Ghazy, N. M., Zdero, C. and Bohlmann, F., Two guaianolides from Cichorium pumilum, Phytochemistry, 23(1), 183-5 (1984) https://doi.org/10.1016/0031-9422(84)83106-4
  15. Steven, F. and Tyler, V. E., Tylers Honest Herbal, A Sensible Guide to the use of Herbs Related to Remedies, 4$^{th}$ Ed., The Hawarth Herbal Press (1992)
  16. Tyler, V. E., Brady, L. R. and Robbers, J. E., Pharmacognosy, 9$^{th}$ ed, Lea and Febiger, Philadelphia, 467 (1988)
  17. Williams, D. H. and Fleming, L., Spectroscopic Methods in Organic Chemistry, 3$^{rd}$ ed., McGraw Hill Book Company (UK) Limited (1980)
  18. Yamoguchi, K., Spectral Data of Natural Products, Vol. 1, Elsevier publishing Co. Amsterdam, London, New York (1970)