대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

시호(柴胡)가 뇌허혈 유발 노령 흰쥐의 해마 손상 및 HSP70 발현에 미치는 영향

Effect of Bupleuri Radix on HSP70 Expression and Hippocampus of Ischemically Damaged Aged BCAO Rats

  • 배철환 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 김진수 (동국대학교 한의과대학 내과학교실)
  • Bae, Cheol-Hwan (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Sung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Gil-Cho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Won-Chul (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jin-Su (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2004.12.30
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초록

Objective : In this study, we used the aged bilateral common carotid artery occlusion (BCAO) rats were used to measure the effect of Bupleuri Radix (Si-Ho) on the brain ischemic injury, because aging is an important factor in storke, Method : The brian ischemic injury was induced by temporary closing of carotids on both sides in a low blood pressure state. Bupleuri Radix (Si-Ho) was orally administered in 18-month-old BCAO rats. Result : The Ischemic Damaged Hippocampus and HSP expression were analyzed by the immunohistochemical staining and the result were as follows: 1. The low numbers of pyramid cells in the hippocampus CA1 area for the ischemically injured experimental group rose to numbers simillar to those of the control group. 2. The thin neuronal cell layer in the hippocampus CA1 area for the ischemically injured experimental group returned to thickness simillar to those of the control group. 3. The normalized optical density of HSP70 expression was suppressed in CA2, DG and CA1 expression was significantly suppressed in the experimental group compared to the control group. Conclusion : These results suggested that Bupleuri Radix (Si-Ho) has a neuroprotective effect by reducing neural cell injury in the initial ischemic state.

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