대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제25권4호
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- Pages.289-299
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- 2004
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- 1226-9174(pISSN)
사람 Mast cell에서의 케모카인에 대한 백연치효탕(白蓮治哮湯)의 효과(效果)
Effect of Baekryunchihyo-tang(白蓮治哮湯) on Expression of Chemokines in Human Mast Cell Line (HMC-I)
- 정희재 (경희대학교 한의과대학 폐계내과학교실) ;
- 이형구 (경희대학교 한의과대학 폐계내과학교실) ;
- 정승기 (경희대학교 한의과대학 폐계내과학교실) ;
- 이형철 (경희대학교 한의과대학 폐계내과학교실)
- Jung, Hee-Jae (Department of Internal Medicine Kang-Nam Kyunghee Oriental Medicine Hospital, College of Oriental Medicine Kyunghee University) ;
- Rhee, Hyung-Koo (Department of Internal Medicine Kang-Nam Kyunghee Oriental Medicine Hospital, College of Oriental Medicine Kyunghee University) ;
- Jung, Sung-Ki (Department of Internal Medicine Kang-Nam Kyunghee Oriental Medicine Hospital, College of Oriental Medicine Kyunghee University) ;
- Lee, Hyung-Chul (Department of Internal Medicine Kang-Nam Kyunghee Oriental Medicine Hospital, College of Oriental Medicine Kyunghee University)
- 발행 : 2004.12.30
초록
Background : Although the pathophysiology of asthma has been reported, its mechanism has not been fully elucidated. The mast cell is an effector cells in allergic inflammation and secretes a number of chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. Chemokines also contribute to the pathogenesis of several disorders such as asthma, chronic bronchitis, atopic dermatitis, allergic rhinitis, and rheumatoid arthritis. Objective : In this study, the aim was to identify the effect of Baekryunchihyo-tang(白蓮治哮湯) on expression of chemokines. This was examined by RT-PCR using the human mast cell line (HMC-l) Materials and Methods : HMC-l cells were used, which is known to secrete and express chemokines. In order to investigate the protective effect of Baekryunchihyo-tang(白蓮治哮湯), HMC-l cells were incubated with pretreatment of Baekryunchihyo-tang(白蓮治哮湯) for 24 hrs. RT-PCR analyses of chemokine genes of cells pretreated with Baekryunchihyo-tang(白蓮治哮湯) showed that expressions of IL-8,