Bulletin of the Korean Chemical Society

  • 제25권2호
  • /
  • Pages.243-248
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  • 2004
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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A Convenient and Versatile Synthesis of 2' (and 3')-Amino (and azido)-2' (and 3')-deoxyadenosine as Diverse Synthetic Precursors of Cyclic Adenosine Diphosphate Ribose (cADPR)

  • Kim, Beom-Tae (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
  • Kim, Seung-Ki (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
  • Lee, Seung-Jae (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
  • Hwang, Ki-Jun (Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
  • 발행 : 2004.02.20
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초록

As diverse synthetic precursors of cyclic adenosine diphosphate ribose (cADPR), several adenosine derivatives in which azido or amino group is introduced at 2'- or 3'-position of the sugar moiety of adenosine were prepared from readily available adenosine via conventional protocols. These synthetic sequence employs very efficient reactions conditions that proceed at or below ambient temperature with actual yields of >80% for each individual step.

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참고문헌

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