Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Oxidative N-Debenzylation of N-Benzyl-N-substituted Benzylamines Catalyzed by Cytochrome P450

  • Kim, Sung-Soo (Department of Chemistry and Center for Chemical Dynamics,Inha University) ;
  • Lin, Gang (Department of Chemistry and Center for Chemical Dynamics,Inha University) ;
  • Yang, Ji-Won (Department of Chemistry and Center for Chemical Dynamics,Inha University)
  • Published : 2004.02.20
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Abstract

Cytochrome P450 (P450)/$O_2$/NADPH engender electron transfer reaction of N-benzyl-N-substituted benzylamines to yield corresponding radical cation 1 that is simultaneously converted into 2 and 3. Subsequently, expulsion of proton and hydroxylation yielding a-hydroxylamines are followed by formation of benzaldehydes and benzylamines.

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