The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

The Anti-tumor Effect of BoJungIkKeeHapDaeChilKi-Tang with Doxorubicin in MKN-45

보중익기합대칠기탕(補中益氣合大七氣湯)과 Doxorubicin의 병용이 MKN-45의 항암효과에 미치는 영향

  • Lee Yun-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Bong-Suk (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Oh Jung-Han (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Lim Hee-Yong (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim Dong-Woo (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Choi Bin-Hye (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Byun Joon-Seok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 이윤희 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김봉석 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 오중한 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 임희용 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김동우 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 최빈혜 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실)
  • Published : 2004.12.01
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Abstract

In order to evaluate the anti-tumor and synergic effect of BoJungIkKeeHapDaeChilKi-Tang on doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and BoJungIkKeeHapDaeChilKi-Tang with their concomitant treatment against MKN-45(Human stomach carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst MKN-45 cell lines. BoJungIkKeeHapDaeChilKi-Tang has only mimic direct anti-tumor effect against to MKN-45 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that BoJungIkKeeHapDaeChilKi-Tang extracts were reduced by the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and BoJungIkKeeHapDaeChilKi-Tang extracts.

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