The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of Lonicerae Flos on bleomycin-induced lung fibrosis

금은화(金銀花)가 Bleomycin에 의한 폐섬유화(肺纖維化)에 미치는 영향(影響)

  • Lee Jae-Sung (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Jung Hee-Jae (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Jung Sung-Ki (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Rhee Hyung-Goo (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 이재성 (경희대학교 한의과대학 폐계내과학교실) ;
  • 정희재 (경희대학교 한의과대학 폐계내과학교실) ;
  • 정승기 (경희대학교 한의과대학 폐계내과학교실) ;
  • 이형구 (경희대학교 한의과대학 폐계내과학교실)
  • Published : 2004.12.01
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Abstract

Objective : Idiopathic Lung Fibrosis(IPF) is chronic fibrotic interstitial pneumonia. The pathogenesis is unclear. Lonicerae Flos is known to prevent the inflammation and reinforce the immune system. The effects of Lonicerae Flos on bleomycin-induced lung fibrosis is evaluated. Material and Methods: Lonicerae Flos extract was given to the Normal rats, control(bleomycin) rats everyday and treated(bleomycin and lonicerae flos) rats 21.0 mg per body weight 109 for 14 days. 14 days after, we observed the change of leukocyte count and percentage of IFN-gamma and IL-4 in BALF. and that of Semiquantative histological index(SHI). Results : Compared to control rats, Lonicerae Flos decreased leukocyte count(P<0.01) lymphocyte, neutrophil percentage(P<0.05), SHI(P<0.01), IFN-gamma and IL-4(P<0.05) in Treated rats. Otherwise, macrophage percentage was increased(P<0.01) in Treated rats. Conclusion : This study showed that Lonicerae Flos reduced the change of inflammatory cells and cytokines in bleomycin-induced lung fibrosis and reduced the fibrosis of tissue. And, we needed many other distinct researches on lung fibrosis.

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