Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Effects of caffeine on capsular fibrous proliferation induced by N-bis(2-hydroxypropyl)nitrosamine and sulfadimethoxine in the thyroid glands

Caffeine이 N-bis(2-hydroxypropyl)nitrosamine과 sulfadimethoxine에 의해 유발된 갑상선 피막의 섬유성 증식에 미치는 영향

  • Son, Hwa-young (College of Veterinary Medicine, Chungnam National University) ;
  • Yoon, Won-kee (Korea Research Institute of Bioscience and Biotechnology) ;
  • Jee, Young-heun (Department of Veterinary Medicine, Cheju National University) ;
  • Ryu, Si-yoon (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Jung-ran (Statistical Training Center, National Institute of Professional Administration) ;
  • Cho, Sung-whan (College of Veterinary Medicine, Chungnam National University)
  • 손화영 (충남대학교 수의과대학) ;
  • 윤원기 (한국생명공학연구원) ;
  • 지영흔 (제주대학교 수의학과) ;
  • 류시윤 (충남대학교 수의과대학) ;
  • 김정란 (국가전문행정연수원 통계연수원) ;
  • 조성환 (충남대학교 수의과대학)
  • Accepted : 2003.11.20
  • Published : 2003.12.25
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Abstract

Caffeine (1,3,7-trimethylxanthine), a central nervous system stimulant, is contained in various foods, beverages and over-the-counter medications. Sulfadimethoxine (SDM) is one of the anti-thyroid agents and induces proliferation of thyroid capsule in two stage thyroid carcinogenesis model using N-bis(2-hydroxypropyl)nitrosamine (DHPN). In this study, we examined the effect of caffeine on fibrous proliferation of thyroid capsule in DHPN and SDM-treated rats. Five-week-old male F344 rats were given a single subcutaneous injection of DHPN (2,800 mg/kg, body weight). Starting one week thereafter, SDM (1,000 ppm in drinking water) with or without caffeine (1,500 ppm in diet) was administered for 12 weeks. All animals were autopsied and histopathological examination of the thyroid glands was performed. Thyroid follicular proliferative changes were induced in all rats treated with DHPN+SDM. In addition, the proliferation of perithyroidal fibrous tissue and pleomorphic thyroid follicular cells within the capsule were observed in DHPN+SDM treated group. Caffeine would not be related to these lesions in this experimental condition. although pentoxifylline, a methyl xanthine derivative, has an anti fibrotic effects.

Keywords

References

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