IMMUNE NETWORK
- 제3권2호
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- Pages.96-102
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Generation of Renal Cell Carcinoma-specific CD4+/CD8+ T Cells Restricted by an HLA-39 from a RCC Patient Vaccinated with GM-CSF Gene-Transduced Tumor Cells
- Jun, Do Youn (Institute of Genetic Engineering, Kyungpook National University) ;
- Moutner, Joseph (GSF-Institut fur Klinische Molekularbiologie) ;
- Jaffee, Elizabeth (Department of Oncology, The Johns Hopkins University School of Medicine)
- 발행 : 2003.06.30
초록
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced tumor cell vaccines induce very potent systemic anti-tumor immunity in preclinical and clinical models. Our previous phase I clinical trial in patients with metastatic renal cell carcinoma (RCC) has demonstrated both immune cell infiltration at vaccine sites and T cell-mediated delayed-type hypersensitivity (DTH) response to whole tumor cell vaccines. Methods: To investigate the immune responses to autologous genetically- modified tumor cell vaccines, tumor-specific