IMMUNE NETWORK
- Volume 3 Issue 3
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- Pages.235-241
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
The Study of MHC class I Restricted CD8+ T Cell Mediated Immune Responses against Mycobacterium tuberculosis Infection: Evidence of M. tuberculosis S pecific CD8+ T Cells in TB Patients and PPD+ Healthy Individuals
MHC class I 분자들에 의해 제시되는 Epitope을 인지하는 CD8+ T 림프구의 결핵균 감염에 대한 면역반응의 연구: 결핵 환자와 PPD+ 건강개체에 존재하는 결핵균 항원에 특정한 CD8+ T세포
- Cho, Jang-Eun (Department of Microbiology, Brain Korea 21 Project for Medical Sciences, Yonsei University Medical Center) ;
- Lee, Kyung Wha (Hallym Institution for Genome Application Hallym University) ;
- Park, Seung Kyu (National Masan Tuberculosis Hospital) ;
- Cheon, Seon-Hee (Department of Internal Medicine, Ewha Womans University Tongdaemun Hospital) ;
- Cho, Sang-Nae (Department of Microbiology, Brain Korea 21 Project for Medical Sciences, Yonsei University Medical Center) ;
- Cho, Sungae (Department of Microbiology, Brain Korea 21 Project for Medical Sciences, Yonsei University Medical Center)
- 조장은 (연세대학교 의과대학 미생물학교실) ;
- 이경화 (한림대학교 유전체응용 연구소) ;
- 박승규 (국립마산결핵병원) ;
- 천선희 (이화여자대학교 의과대학 동대문병원) ;
- 조상래 (연세대학교 의과대학 미생물학교실) ;
- 조성애 (연세대학교 의과대학 미생물학교실)
- Published : 2003.09.30
Abstract
Background: The protective immunity against tuberculosis (TB) involves both CD4+ T cells and CD8+ T cells. In our previous study, we defined four Mycobacterium tuberculosis derived peptide epitopes specific for HLA-
Keywords
- Mycobacterium tuberculosis;
- CD8+ T cells;
- peptide epitopes;
- HLA-$A^*0201$;
- IFN-${\gamma}$ elispot assay