IMMUNE NETWORK
- Volume 3 Issue 4
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- Pages.287-294
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- 2003
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Inhibition of Graft Versus Host Disease Using CD4+CD25+ T Cells Induced with Interleukin-2 in Mismatched Allogeneic Murine Hematopoietic Stem Cell Transplantation
주조직적합항원이 불일치하는 마우스 동종 조혈모세포이식에서 IL-2로 유도된 CD4+CD25+ T세포를 이용한 이식편대숙주병의 억제
- Hyun, Jae Ho (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
- Jeong, Dae Chul (Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
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Chung, Nak Gyun
(Department of Pediatrics, College of Medicine, The Catholic University of Korea) ;
- Park, Soo Jeong (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
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Min, Woo Sung
(Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
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Kim, Tai Gyu
(Department of Microbiology, College of Medicine, The Catholic University of Korea) ;
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Choi, Byung Ock
(Department of Radiation Oncology College of Medicine, The Catholic University of Korea) ;
- Kim, Won Il (Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea) ;
- Han, Chi Wha (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
- Kim, Hack Ki (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
- 현재호 (가톨릭대학교 의과대학 소아과학교실) ;
- 정대철 (가톨릭대학교 의과대학 소아과학교실) ;
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정낙균
(가톨릭대학교 의과대학 소아과학교실) ;
- 박수정 (가톨릭대학교 의과대학 내과학교실) ;
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민우성
(가톨릭대학교 의과대학 내과학교실) ;
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김태규
(가톨릭대학교 의과대학 미생물학교실) ;
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최병옥
(가톨릭대학교 의과대학 치료방사선과학교실) ;
- 김원일 (가톨릭대학교 의과대학 진단병리과) ;
- 한치화 (가톨릭대학교 의과대학 내과학교실) ;
- 김학기 (가톨릭대학교 의과대학 소아과학교실)
- Published : 2003.12.30
Abstract
Background: In kidney transplantation, donor specific transfusion may induce tolerance as a result of some immune regulatory cells against the graft. In organ transplantation, the immune state arises from a relationship between the immunocompromised graft and the immunocompetent host. However, a reverse immunological situation exists between the graft and the host in hematopoietic stem cell transplantation (HSCT). In addition, early IL-2 injections after an allogeneic murine HSCT have been shown to prevent lethal graft versus host disease (GVHD) due to CD4+ cells. We investigated the induction of the regulatory CD4+CD25+ cells after a transfusion of irradiated recipient cells with IL-2 into a donor. Methods: The splenocytes (SP) were obtained from 6 week-old BALB/c mice (