한국수산과학회지 (Korean Journal of Fisheries and Aquatic Sciences)

  • 제36권6호
  • /
  • Pages.573-577
  • /
  • 2003
  • /
  • 0374-8111(pISSN)
  • /
  • 2287-8815(eISSN)
한국수산과학회 (The Korean Society of Fisheries and Aquatic Science)
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노닐페놀을 주사한 조피볼락의 신장 MFO (mixed function oxidase)의 반응

Responses of Renal Mixed Function Oxidase System in Rockfish (Sebastes schlegeli) Administered with 4-Nonylphenol

  • 전중균 (강릉대학교 해양생명공학부/동해안해양생물자원연구센터) ;
  • 이지선 (강릉대학교 해양생명공학부/동해안해양생물자원연구센터) ;
  • 손영창 (강릉대학교 해양생명공학부/동해안해양생물자원연구센터) ;
  • 홍경표 (한국해양연구원 해양생물자원연구본부) ;
  • 심원준 (한국해양연구원 남해연구소) ;
  • 김병기 (강원도립대학 해양생물자원개발과) ;
  • 한창희 (동의대학교 생명과학부)
  • 발행 : 2003.12.01
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초록

Effects of 4-nonylphenol (4-NP) on mixed function oxygenase (MFO) in the kidneies of rockfish (Sebastes schlegeli) were investigated. The cytochrome P45O (CYP) contents and NADPH cytochrome P450 reductase, NADH cytochrome b5 reductase and 7-ethoxyredorufin-O-deethylase (EROD) activities of microsome, glutathione S-transferase (GST) activity of cytosol in rockfish exposed to 4-NP for 7 days using an intraperitoneal injection (25 mg/kg) were quantitatively determined. The GST activity of rockfish exposed to 4-NP were higher, up to 5.2 times higher, than those in the control fish. The activities of NADPH-and NADH-dependent reductases were inhibited. On the other hand, CYP contents and EROD activity of the 4-NP exposed fish demonstrated neither an increasing or decreasing trend.

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참고문헌

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