Fine Needle Aspiration Cytology of Biphasic Synovial Sarcoma - A Case Report -

이중상 활막육종의 세침흡인 세포학적 소견 -1예 보고-

  • Kim, Hee-Kyung (Department of Pathology, Yonsei University College of Medicine) ;
  • Jin, So-Young (Department of Pathology, Soonchunhyang University Hospital) ;
  • Lee, Dong-Wha (Department of Pathology, Soonchunhyang University Hospital)
  • 김희경 (연세대학교 병리학교실) ;
  • 진소영 (순천향대학교병원 병리과) ;
  • 이동화 (순천향대학교병원 병리과)
  • Published : 2003.11.30

Abstract

Synovial sarcoma is a rare soft tissue tumor accounting for 5-10% of soft tissue sarcomas. Most arise in the extremities and trunk, and a small proportion occur in the abdominal wall, head and neck legion, and mediastinum. It manifests different phenotypic subtypes that render their cytologic evaluation challenging. Moreover, cytomorphologic description of the epithelial component of synovial sarcoma is rare in Korea. We report a case of biphasic synovial sarcoma on the right lower extremity in a 49-year-old woman diagnosed by fine needle aspiration cytology. The aspirate was moderately cellular and composed of a mixture of tissue fragments and dissociated cells with bland chromatin, inconspicuous nucleoli, and oval to spindle-shaped cytoplasm. Mitosis was rare. A monolayer sheet of epithelial component was seen. The cells in this monolayer sheet had more abundant distinct cytoplasm, round nuclei, and prominent micronucleoli. Histologic examination showed a biphasic pattern consisting of mostly sarcomatous stroma and a few small glandular areas at the periphery of the tumor.

Keywords

References

  1. Koivuiemi A, Nickels J. Synovial sarcoma diagnosed by fine-needle aspiration biopsy : A case report. Acta Cytol 1978;22:515-8
  2. Sapi Z, Bodo M, Negyesi J, Rahoty P. Fine needle aspiration cytology of biphasic synovial sarcoma of soft tissue : Report of a case with ultrastructural,. immunohistologic and cytophotometric studies. Acta Cytol 1990;34:69-73
  3. Aisner SC, Seidman JD, Burke KC, Youg JW. Aspiration cytology of biphasic and monophasic synovial sarcoma : A report of two cases. Acta Cytol 1993;37:413-7
  4. Akerman M, Willen H, Carlen B, Mandahl N, Mertens F. Fine needle aspiration(FNA) of synovial sarcoma : a comparative histological-cytological study of 15 cases, including immunohistochemical, electron microscopic and cytogenetic examination and DNA-ploidy analysis. Cytopathology 1996;7:187-200 https://doi.org/10.1046/j.1365-2303.1996.38782397.x
  5. Kilpatrick SE, Tet LA, Stanley MW, Ward WG, Savage PD, Geisinger KR. Fine-needle aspiration biopsy of synovial sarcoma: A cytomorphologic analysis of primary, recurrent, and metastatic tumor. Am J Clin Pathol 1996;106:769-75 https://doi.org/10.1093/ajcp/106.6.769
  6. Ryan MR, Stastny JF, Wakely PE. The cytopathology of synovial sarcoma : A study of six cases, with emphasis on architecture and histopathologic correlation. Cancer(Cancer Cytopathol) 1998;84:42-9 https://doi.org/10.1002/(SICI)1097-0142(19980225)84:1<42::AID-CNCR7>3.0.CO;2-H
  7. Viguer JM, Jinenez-Heffeman JA, Vicandi B, Lopez-Ferrer P, Gamallo C. Cytologic features of synovial sarcoma with emphasis on the monophasic fibrous variant: A morphologic and immunohistochemical analysis of bcl-2 protien expression. Cancer(Cancer Cytopathol) 1998;84:50-6
  8. Klijanienko J, Caillaud JM, Lagace R, Vieih P. Cytohistologic correlations in 56 synovial sarcomas in 36 patients : The institut curie experience. Diagn Cytopathol 2002;27:96-102 https://doi.org/10.1002/dc.10151
  9. Akernan M, Ryd W, Skytting B. Fine-needle aspiration of synovial sarcoma : Criteria for diagnosis : Retrospective reexamination of 37 cases, including ancillary diagnostics. A scandinavian sarcoma group study. Diagn Cytopathol 2003;28:232-8
  10. Krall RA, Kostianovsky M, Patchefsky AS. Synovial sarcoma : a clinical, pathological, and ultrastructural study of 26 cases supporting the recognition of a monophasic variants. Am J Surg Pathol 1981;5:137-51 https://doi.org/10.1097/00000478-198103000-00005
  11. Enzinger FM, Weiss SE. Synovial sarcoma. In : Enzinger FM, Weiss SE. Soft tissue tumors. 4th ed. St. Louis: C.V.Mosby, 2001;1483-509
  12. Fisher C. Synovial sarcoma. Curr Diagn Pathol 1994;1: 13-8 https://doi.org/10.1016/S0968-6053(06)80004-9
  13. Fletcher CDM. Hemangiopericytoma - A dying breed? Reappraisal of an 'entity' and its variants : a hypothesis. Curr Diagn Pathol 1994;1: 19-23 https://doi.org/10.1016/S0968-6053(06)80005-0
  14. Enzinger FM, Weiss SE. Fibrosarcoma. In; Enzinger FM, Weiss SE. Soft tissue tumors. 4th ed. St Louis: C.V. Mosby, 1995;409-37
  15. Willen H, Akerman M, Carlen B. Fine needle aspiration (FNA) in the diagnosis of soft tissue tumors: a review of 22 year experience. Cytopathology 1995;6:236-47 https://doi.org/10.1111/j.1365-2303.1995.tb00475.x
  16. Gonzales-Campora R, Munoz-Arias G, Otal-Salaverri C, et al. Fine needle aspiration cytology of primary soft tissue tumors: morphologic analysis of the most frequent types. Acta Cytol 1992;36:905-17
  17. Orell SR, Sterrett GF, Walters MNl, Whitaker O. Manual and atlas of fine needle aspiration cytology. 2nd ed. Edinburgh: Churchill Livingstone, 1992;310,318,322
  18. Vendraminelli F, Cavazzana AO, Poletti A, Galligioni A, Pennelli N. Fine-needle aspiration cytology of malignant nerve sheath tumors. Oiagn Cytopathol 1992;8:559-62 https://doi.org/10.1002/dc.2840080603
  19. Fisher C. Poorly differentiated synovial sarcoma. Pathol Case Rev 1998;3:123-7 https://doi.org/10.1097/00132583-199805000-00006
  20. Van de Rijn M, Barr FG, Xiong QB, Hedges M, Shipley J, Fisher C. Poorly differentiated synovial sarcoma: an analysis of clinical, pathological and molecular genetic features. Am J Surg Pathol 1999;23:106-12 https://doi.org/10.1097/00000478-199901000-00012