Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
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Uncertainty evaluation of dioxin analysis in blood samples

혈액 시료 중 다이옥신의 농도 분석 결과에 대한 불확도 평가

  • Mun, Su-Jung (School of Environmental Science and Engineering, Pohang University of Science and Technology) ;
  • Kim, Byung-Hoon (School of Environmental Science and Engineering, Pohang University of Science and Technology) ;
  • Woo, Jin-Chun (Inorganic Analytical Chemistry Group, Korea Research Institute of Standards and Science) ;
  • Chang, Yoon-Seok (School of Environmental Science and Engineering, Pohang University of Science and Technology)
  • 문수정 (포항공과대학교 환경공학부) ;
  • 김병훈 (포항공과대학교 환경공학부) ;
  • 우진춘 (한국표준과학연구원 무기분석그룹) ;
  • 장윤석 (포항공과대학교 환경공학부)
  • Received : 2003.06.07
  • Accepted : 2003.10.30
  • Published : 2003.12.25
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Abstract

Uncertainty of final measurement results considering main uncertainty sources being in dioxin analysis of a blood sample was estimated. 'The Guide to the Expression of Uncertainty in Measurement' was suggested for accomplishment of this study. After uncertainties for the 11 compounds detected in this experiment of the 17 target compounds of dioxin and furan were calculated considering the uncertainty sources of each step, uncertainty for the total dioxin concentration was estimated by combining these values. The concentration of dioxin in blood sample was expressed as $0.0746{\pm}0.0074pg$ I-TEQ/g weight or $20.68{\pm}2.04pg$ I-TEQ/g lipid, including the uncertainty values obtained in this way. The former expression indicates the conversion concentration into the sample weight and the latter one indicates the conversion concentration into the lipid weight. The quality of measured analytical results could be assured quantitatively by estimating uncertainty of measurement results and showing the range of measurand.

혈액 시료 중의 다이옥신 농도를 분석하는 과정에서 있을 수 있는 중요한 오차요인들을 고려하여 최종적인 측정 결과에 대한 불확도를 구하였다. 불확도의 평가 원리는 측정 불확도 표현 지침서를 따랐으며, 불확도를 구하는 방법도 이 지침서를 참고하여 수행되었다. 각 측정 과정의 불확도 요인을 고려하여 다이옥신 및 퓨란의 주요 17가지 이성질체 중 이 실험에서 농도가 검출된 11가지 이성질체에 한하여 각각에 대한 불확도를 구한 후, 이 값들을 합성하여 총 다이옥신 농도에 대한 불확도를 구하였다. 이렇게 하여 얻은 불확도를 함께 나타낸 최종 다이옥신 농도는 $0.0746{\pm}0.0074pg$ I-TEQ/g weight 또는 $20.68{\pm}2.04pg$ I-TEQ/g lipid 이었다. 전자는 시료의 무게당 환산농도로 나타낸 것이며, 후자는 지방의 무게당 환산농도로 나타낸 것이다. 이와 같이, 측정 결과에 대한 불확도를 구하여 측정량의 존재 범위를 나타냄으로써 분석 결과의 품질을 정량적으로 보증할 수 있다.

Keywords

Acknowledgement

Supported by : 환경부, 한국학술 진흥재단

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