Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of the Geijibokryunghwan on human hepatocarcinoma cells

  • Lee Soo Kyung (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Kim Han Geu (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Ahan Jong Chan (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Chung Tae Wook (Department of Diagnostics, College of Oriental Medicine, Dongguk University) ;
  • Moon Jin Young (Department of AM-Pointology, College of Oriental Medicine, Dongguk University) ;
  • Park Sun Dong (Department of Prescription, College of Oriental Medicine, Dongguk University) ;
  • Kim June Ki (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Choi Dall Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim Cherl Ho (Department of Biochemistry, College of Oriental Medicine, Dongguk University) ;
  • Park Won Hwan (Department of Diagnostics, College of Oriental Medicine, Dongguk University)
  • Published : 2003.04.01
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Abstract

We invesgated the GBH water extracts can be used as a potential cancer chemopreventive agent in humans, especially in hepatological cancer cell lines. The GBH was found to act as an potent inhibitor of COX-I only, but not as COX-2 inhibitor. Furthermore, the extract mediated anti-inflammatory effects and inhibited COX-associated hydroperoxidase functions(antipromotion activity). Inhibitory effect of the GBH water extracts on the growth of cancer cell lines such as HepG2 cell and Hep3B cell was shown.

Keywords

References

  1. Fed. Proc. v.38 Chemoprevention of cancer with retinoids. Sporn, M.B.; Newton, D.L.
  2. Gann v.71 Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats. Kudo, T.;Narisawa, T.;Abo, S.
  3. Cancer Lett. v.21 The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat. Pollard, M.;Luckert, P.H.;Schmidt, M.A. https://doi.org/10.1016/0304-3835(83)90082-4
  4. Am. J. Sur. v.157 Sulindac for polyposis of the colon. Waddell, W. R.;Ganser, G.R.;Cerise, E.J.;Loughry, R.W. https://doi.org/10.1016/0002-9610(89)90442-X
  5. New Engl. J. Med. v.325 Aspirin use and reduced risk of fatal colon cancer. Thun, M.J.;Namboodiri, M.M.;Heath, C.W. https://doi.org/10.1056/NEJM199112053252301
  6. Proc. Natl. Acad. Sci. USA. v.72 Subversion of immune system by tumor cells and role of prostaglandins. Plescia, O.J.;Smith, A.H.;Grinwich, K. https://doi.org/10.1073/pnas.72.5.1848
  7. Am. J. Med. v.77 : Immunologic effects of nonsteroidal anti-¬inflammatory drugs. Goodwin, J.S. https://doi.org/10.1016/0002-9343(84)90429-7
  8. J. Pharmacal. Exp. Ther. v.227 Prostaglandin H synthase-catalyzed activation of benzidine: a model to assess pharmacologic intervention of the initiation of chemical carcinogenesis. Zenser, T.V.
  9. Carcinogenesis v.8 Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type. Wild, D.;Degan, G. H. https://doi.org/10.1093/carcin/8.4.541
  10. Gann v.59 Antitumor action of some Basidiomycetes, especially Phllinus inteus. Ikekawa,T.;Nakanishi, M.;Uehara, N.;Chihara, G.;Fukuoka F.
  11. Gann v.56 Mechanism of antitumor action of some plant polysaccharides. Tanaka, T.;Fukuoka, F.;Nakahara, W.
  12. Cancer Res. v.38 beta(l leads to 3) Glucan-mediated augmentation of alloreactive murine cytotoxic T-Iymphocytes in vivo. Hamuro, J.;Rollinghoff, M.;Wagner, H.
  13. The J. of the Korea institute of oriental medical diagnostics v.4 An experimental study on the effect of Geijibokryunghwan, Dangguijakyaksan and each constituent herb on inhibition of platelet aggregation Kim, J.G.;Kim, C.H.;Park, S.Y.;Kim, J.S.;Choi, J.Y.;Kim, C.H.;Park, W.H.
  14. 금궤요략단석 杜雨戊;張聯惠
  15. 漢藥臨床應用 李尙仁(外5人)
  16. 血瘀證與活血化瘀硏邱 陳可翼(外3人)
  17. 금궤요략 李克光
  18. J. Biol. Chem v.193 Lowry, H.O.;Rosenberough, A.;Farr L.;Randall, J.R.
  19. Methods Enzymol. v.86 Purification of PGH synthase from sheep vesicular glands. Van der Ouderaa, F.J.G.;Muytenhek, M. https://doi.org/10.1016/0076-6879(82)86169-7
  20. Prostaglandins and Related Substances. A Practical Approach Kulmacz, R.J.;Lands, E.M.;C. Benedetto;RG. McDonald-Gibson;S. Nigam;T.F. Slater(Eds.)
  21. : in Chemistry and Biochemistry of Retinoids Moon, R.C.;Mehta, R.G.
  22. Chinese-English manual of common-used Effect of the Geijibokryunghwan on human hepatocarcinoma cells prescriptions in TCM Ming, O.
  23. Chinese-English terminology of traditional chinese medicine Su Hak Choong
  24. Cancer Res. v.53 Prevention--therapy--basic science and the resolution of the cancer problem. Wattenberg, L.W.
  25. Biochem. J. v.305 Expression and selective inhibition of the constitutive and inducible forms of human cydo¬oxygenase. Gierse, J.K. https://doi.org/10.1042/bj3050479