Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Therapeutic Effects of Ephedra sinica Stapf Herb-Acupuncture on Adjuvant-induced Polyarthritis of Rat

흰쥐의 Adjuvant 유발 다발성 관절염에 대한 마황 약침의 치료 효과

  • Lee Han-Chang (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Yeom Mijung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Gun-Ho (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Shim In-Sop (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Choi Kang-Duk (East-West Kidney Center, Kyunghee Medical Center) ;
  • Lee Hye-Jung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Hahm Dae-Hyun (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyunghee University)
  • 이한창 (경희대학교 동서의학대학원) ;
  • 염미정 (경희대학교 동서의학대학원) ;
  • 김건호 (경희대학교 동서의학대학원) ;
  • 심인섭 (경희대학교 동서의학대학원) ;
  • 최강덕 (경희대학교 의과대학 동서신장센터) ;
  • 이혜정 (경희대학교 동서의학대학원) ;
  • 함대현 (경희대학교 동서의학대학원)
  • Published : 2003.04.01
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Abstract

The current studies investigated the therapeutic effects of Ephedra sinica Stapf (ES) herb-acupuncture on the inflammatory responses of rat arthritic joint, which was induced by the intradermal injection of heat-killed Mycobacterium tuberculosis emulsified in squalene to the base of the tail. The measurements of body weight and articular index were exploited as the assessment methods addressing arthritic symptoms, and the expression profiles of cytokines such as TNF-α, IL-1β and IL-6 in the rat joint were analyzed using RT-PCR. The articular indexes of arthritic rats were significantly restored after the treatment with ES herb-acupuncture. Although the clinical symptoms of arthritic rats were apparently alleviated by the ES treatments, their body weights were not recovered. It maybe due to the weight-loss and energy enhancement effects of ES extracts. The expression of TNF-α, IL-1β and IL-6 genes, which were highly stimulated in the knee joints of arthritic rats, were restored to the levels of normal rats after the ES treatment. The therapeutic effect of ES herb-acupuncture was not observed in ES-treated, non-acupoint arthritic group as a sham control. The ES herb-acupuncture into an acupoint ST36 was found to be effective in alleviating the arthritic symptoms in adjuvant-induced arthritis rats as regards the body weight, joint appearance and the expression profiles of inflammatory cytokines.

Keywords

References

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