Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Radix Polygoni Multiflori on Spinal Motor Neurons Damaged by Methylmercuric Chloride

메틸수은으로 손상된 척수신경세포에 대한 하수오의 영향

  • Ha Dae Ho (School of Medicine Wonkwang University) ;
  • Lee Byung Chan (School of Medicine Wonkwang University) ;
  • Lee Kang Chang (Department of Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Whan Bong (School of Medicine Wonkwang University, Institute of Wonkwang Science)
  • 하대호 (원광대학교 의과대학) ;
  • 이병찬 (원광대학교 의과대학) ;
  • 이강창 (원광대학교 한의학전문대학원) ;
  • 이환봉 (원광대학교 의과대학, 원광의과학연구소)
  • Published : 2003.06.01
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Abstract

In order to evaluate the cytotoxicity of methylmercuric chloride(MMC) in cultured spinal motor neurons of neonatal mouse, cell viability was measured by MTT assay in spinal motor neurons treated with 1-30 μM MMC for 48 hours. And also, the protective effect of Radix Polygoni Multiflori(RPM) was examined by cell viability in these cultures. Cell viability was significantly decreased in dose-dependent manner after cultured cells were exposured to 20 μM MMC for 48 hours. Protective effect of RPM on MMC-mediated toxicity was very effective in these cultures. From above the results, it suggests that MMC has toxic effect in cultured mouse spinal motor neurons and herb extract such as RPM is very effective in blocking the neurotoxicity induced by MMC.

Keywords

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