Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Unripened fruits and Ripened fruits of Rubus coreanus Miquel on Murine Peritoneal Macrophages

복분자 미숙과 및 성숙과가 생쥐의 복강 Macrophages에 미치는 영향

  • Lee Taek Yul (College of Pharmacy, Woosuk University) ;
  • Kim Dae Keun (College of Pharmacy, Woosuk University) ;
  • So June No (College of Science and Technology, Woosuk University) ;
  • Kwon Jin (Department of Health Administration, Kunjang College) ;
  • Song Jung Mo (College of Oriental Medicine, Woosuk University) ;
  • Eun Jae Soon (College of Pharmacy, Woosuk University)
  • Published : 2003.08.01
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Abstract

The purpose of this research was to investigate the effects of unripened fruits and ripened fruits of Rubus coreanus Miquel on murine peritoneal macrophages. The 70% ethyl alcohol extracts (20 or 100 mg/kg) of unripened fruits (RCE-I) and of ripened fruits (RCE-II) were administered p.o. once a day for 7 days to mice. RCE-I and RCE-II decreased the phagocytic activity of murine peritoneal macrophages and the production of nitric oxide. Also, RCE-I and RCE-II increased the production of tumor necrosis factor- a from peritoneal macrophages. In general, the immuno-suppressive action of RCE-I on macrophages was more potent than those of RCE-II. These results suggest that the fruits of Rubus coreanus Miquel regulates the non-specific immune response via decrease of phagocytic activity and increase of production of tumor necrosis factor- a from murine peritoneal macrophages.

Keywords

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