Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Sojagangqi-tang on the Immunomodulatory Action

소자강기탕의 면역조절효과

  • Shin Hyun Jong (Department of Pathology. College of Oriental Medicine. Woosuk University) ;
  • Jeong Sang Hun (Department of Pathology. College of Oriental Medicine. Woosuk University) ;
  • Jeong Han Sol (Department of Pathology. College of Oriental Medicine. Woosuk University) ;
  • Lee Kwang Gyu (Department of Pathology. College of Oriental Medicine. Woosuk University)
  • 신현종 (우석대학교 한의과대학 병리학교실) ;
  • 정상훈 (우석대학교 한의과대학 병리학교실) ;
  • 정한솔 (우석대학교 한의과대학 병리학교실) ;
  • 이광규 (우석대학교 한의과대학 병리학교실)
  • Published : 2003.10.01
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Abstract

The purpose of this research was to investigate the effect of Sojagangqi-tang(SJGQT) on the immune cell activity. The addition of SJGQT enhanced the proliferation of cultured-mice splenocytes and thymocytes. Administration of SJGQT(250 mg/kg) accelerated the subpopulation of splenic T lymphocytes especially CD/sup 4+/-TH cells in BALB/c mice. But high concentration(500 mg/kg) of SJGQT decreased the splenic T, B lymphocytes and thymic Tc (CD/sup 8+/) lymphocytes. Oral administration of SJGQT(250 mg/kg) significantly enhanced the production of IFN-γ and IL-4 in mice serum. And also, the addition of SJGQT(100 ㎍/ml) inhibited the proliferation of cultured-Jurkat leukemia cells in vitro. These results suggest that SJGQT have a cellular immuno-modulatory effect and anti-cancer property action

Keywords

References

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