Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Gunjung-tang on Allergic Reaction

알레르기 반응에 미치는 건중탕의 효과

  • Kang Kyung Hwa (Department of Physiology, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University) ;
  • Choi Yung Hyun (Department of Anatomy, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University) ;
  • Choi Byung Tae (Department of Biochemistry, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University) ;
  • Lee Yong Tae (Department of Physiology, College of Oriental medicine, Research Institute of Oriental medicine, Dongeui University)
  • 강경화 (동의대학교 한의과대학 생리학교실ㆍ동의대학교 한의과대학 한의학연구소) ;
  • 최영현 (동의대학교 한의과대학 해부학교실ㆍ동의대학교 한의과대학 한의학연구소) ;
  • 최병태 (동의대학교 한의과대학 생화학교실ㆍ동의대학교 한의과대학 한의학연구소) ;
  • 이용태 (동의대학교 한의과대학 생리학교실ㆍ동의대학교 한의과대학 한의학연구소)
  • Published : 2003.12.01
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Abstract

Gunjung-tang(GJT) has been reported at Shanghanlun(傷寒論), which has been used for the treatment of general weakness, digestive organ disease and the treatment of allergic disorders in clinical medicine. However, its effect in experimental models remains unknown. In a rat and mouse model, the role of GJT was examined in mast cell-dependent allergic reactions and secretion of inflammatory cytokines. GJT inhibited anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by Intraperitoneal pretreatment. GJT inhibited both IL-1β and TNF-α secretion on egg albumin induced allergic tissues and compound 48/80 induced thymus. Furthermore, GJT enhanced Band T lymphocytes proliferation. Our findings provide evidence that GJT inhibits the IgE-dependent allergic reactions and inflammatory cytokines secretion, and enhanced immune response.

Keywords

References

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