The Combined Effect of Moschus and Anti-tumor drug Mitomycin C

사향과 항암제 Mitomycin C의 병용효과

  • Published : 2003.12.01

Abstract

The combined effects of water-soluble fraction of Moschus (ME) and anti-tumor drug mitomycin C on the proliferation of human tumor cell-lines were estimated by MTT colorimetric assay. ME inhibited the proliferation of Hep G2, A540, HeLa, KHOS-NP and Balb/c 3T3 cells. Also, ME increased the cytotoxicity of mitomycin C on Hep G2, A549 and HeLa cells. In addition, ME enhanced the cell viability of murine splenocytes and human lymphocytes at the concentration of 100㎍/㎖. These results indicate that ME inhibits the proliferation of human tumor cells and increases the cytotoxicity of mitomycin C without cytoxicity on immune cells.

Keywords

References

  1. 現代生藥學 生藥學硏究會
  2. Oyo Yakuri. v.33 no.4 Pharmacological actions of muscone on cardiovascular system Toyoguchi, Y.;Satoh, H.;Otorii, T.;Sugawara, K.
  3. Planta Med. v.49 Stucture of hydroxymuscopyridine A and hydroxymuscopyridine B, two new constituents of musk Yu, D.;Das, B.C.
  4. 藥誌 v.98 動物性生藥の 品質評價に關する硏究(弟2報). 麝香の品質評價に關する硏究 久保喜一(等)
  5. Chem. Pharm. Bull. v.23 no.3 Study on the Components of Musk(I) Do, J.C.;Kitatsuji, E.;Yoshii, E.
  6. Acta Pharmaceutica Sinica v.15 Studies on the anti-inflammatory principle of musk Yu, D.(et al)
  7. Tetrahedron Letters v.32 no.14 M usclide-A1, -A2, and -B, Cardiotonic potentiating Principles from Musk Kadota, S.;Orito, T.;Kituchi, T.;Uwano, T.;Kimura, I.;Kimura, M.
  8. Yakugaku Zasshi. v.88 no.2 Fundamental Research for the pharmacological Activity of Oriental Drugs.Ⅶ. Kimura, M.;Osada, E.;Waki, I.
  9. Yakugaku Zasshi. v.98 no.4 Fundamental Research for the Pharmacological Activity of Oriental Drugs kimura, M.;Waki, I.;Inagaki, J.
  10. Phytotherapy Research v.3 no.3 Forskolin-and Diacylglycerol-like Potentiation of Isoproterenol- induced Positive Inotropic effect in Guinea pig Papillary Muscles by the Musk Component, Musclide. Kimura, M.;Kimura, I.;Chui, L.;Uwano, T.
  11. Phytotherapy Research v.5 Musclide-A1: A novel $Ca^2+$-dependent protein kinase activator derived from musk and its cardiotonic potentiating action in guinea-pig cardia muscles Kimura, M.;Kimura, I.;Uwano, T.;Isoi, Y.;Kadota, S.;Kikuchi, T.
  12. Taisha. v.29 no.5 Musclide-$A_1$; A Novel Cardiotonic Compound Derived from Musk and its Pharmacological Mechanisms Kimura, I.;Kimura, M.
  13. Zhongguo Zhong Yao Za Zhi. v.15 no.1 Analgesic anti-inflammatory effects of moschus bone setting liquor in local traumatic ecchymosis Ding, M.;Lin, W.
  14. Acta Pharmaceutica Sinica. v.23 no.6 The pharmacological activities of Musk(Ⅱ) Zhu, X.Y.;Wang, W.J.;Xu, G.F.;Yang, Y.L.;Sun, S.M.;Xue, L.M.
  15. Journal of Pharmacy and Pharmacology v.14 Anti-inflammatory Activity of Musk Mishra, R.K.;Arora, R.B.;Seth, S.D.S.
  16. Yakugaku Zasshi. v.98 no.4 Fundamental Research for the Pharmacological Activity of Oriental Drugs kimura, M.;Waki, I.;Ishida, M.
  17. Yao Hsueh Hsueh Pao. v.15 no.5 Studies on the antiinflammatory Principle of Musk Dequan, Y.;Xuemei, L.;Shuyan, G.
  18. Gen. Pharmac. v.18 no.3 Pharmacological properties of Musk Morishita, S.;Mishima, Y.;Shoji, M.
  19. The Indian Journal of Pharmacy v.35 no.6 Cardiac and CNS Actions of Musk Mukhopadhyay, A.;Seth, S.D.S.;Bagchi, N.
  20. Japanese Journal of Pharmacology v.23 Antihistamic and Spasmolytic effects of Musk Seth, S.D.S.;Mukhopadhyay, A.;Bagchi, N.;Prabhakar, M.C.;Arora, R.B.
  21. 抗癌本草 常敏毅
  22. The combined effects of 50% MeOH extract of Bezoar Bovis and anti-cancer drugs on human cancer-cell lines Eun, J.S.;Kang, S.Y.;Han, J.H.
  23. 生藥分析の 投法, 厚生科學硏究報告(2) 高桑德太郞(外)
  24. American type culture collection.$7^th$ Catalogue of cell lines and hybridomas Robert, Hay.(et al)
  25. $D_1.$ J. Immunol. v.120 Characterization of lymphocyte-activating factor(LAF) produced by the macrophage cell line Misel, S.B.;Opinheim, J.J.;Rosensteich, K.L.
  26. Selected methods in cellular immunology Mishell, B.B.;Shiigi, S.M.
  27. J. Immunol. methods. v.65 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays Mosmann, T.
  28. J. Immunol. methods. v.129 A simple and rapid method to determine hematopoietic growth factor activity Kotnic, V.;Fleischmann, W.R. Jr.
  29. 方藥合編解說 申載鏞
  30. 漢方藥 奧田拓道;木村正康;官本昭正;和田(博)