Diterpenoids from the Stem Barks of Croton robustus

  • Nattya-Ngamrojnavanich (Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University) ;
  • Sorasaree-Tonseiengsom (Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University) ;
  • Preecha-Lertpratchya (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University) ;
  • Sophon-Roengsumran (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University) ;
  • Songchan-Puthong (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University) ;
  • Amorn, Petsom (lnstitute of Biotechnology and Genetic Engineering, Chulalongkorn University)
  • Published : 2003.11.01

Abstract

Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic, acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with $ED_{50}$ of 9.2, 9.6 and 8.3, $9.1{\mu\textrm{g}}/mL$, respectively.

Keywords

References

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