Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anti-Tumor Activities of Decursinol Angelate and Decursin from Angelica gigas

  • Lee, Sang-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University, College of Pharmacy, Seoul National University) ;
  • Lee, Yeon-Sil (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Jang, Sang-Hoon (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kim, Bak-Kwang (College of Pharmacy, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University, College of Pharmacy, Seoul National University)
  • Published : 2003.09.01
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Abstract

The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.

Keywords

References

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