Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antioxidative Constituents from Buddleia officinalis

  • Piao, Mei-Shan (College of Pharmacy, Chosun University) ;
  • Kim, Mi-Ran (Research Center for Proteineous Materials, Chosun University) ;
  • Lee, Dong-Gun (School of Life Science and Biotechnology, Kyungpook National University) ;
  • Park, Yoonkyung (Research Center for Proteineous Materials, Chosun University) ;
  • Hahm, Kyung-Soo (Research Center for Proteineous Materials, Chosun University) ;
  • Moon, Young-Hee (College of Pharmacy, Chosun University) ;
  • Woo, Eun-Rhan (College of Pharmacy, Chosun University, Research Center for Proteineous Materials, Chosun University)
  • Published : 2003.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Four flavonoids (1-4), a phenylethyl glycoside (5), and a phenylpropanoid glycoside (6) were isolated from the flowers of Buddleia officinalis (Loganiaceae). Their structures were determined by chemical and spectral analysis. Among the isolated compounds, luteolin (1) and acteoside (6) exhibited the most potent antioxidative activity on the NBT superoxide scavenging assay. In addition, compounds 1-6 revealed weak antifungal activity, and no hemolytic activity.

Keywords

References

  1. Akdemir, Z. S., Tati, ii., Saraccoglu, i., ismailoglu, U. B., Sahin-Erdemli, i., and Calis, i., Polyphenolic compounds from Geranium pratense and their free radical scavenging activities. Phytochemistry, 56, 189-193 (2001) https://doi.org/10.1016/S0031-9422(00)00367-8
  2. Blondle, S. E. and Houghten, R. A., Design of model amphipathic peptides having potent antimicrobial activities. Biochemistry, 31, 12688-12694 (1992) https://doi.org/10.1021/bi00165a020
  3. Ding, N., Yahara, S., and Nohara, T., Structure of mimengoside A, and B, new triterpenoid glycosides from Buddlejae Flos produced from China. Chem. Pharm. Bull., 40, 780-782 (1992) https://doi.org/10.1248/cpb.40.780
  4. Fan, W., Tezuka, Y., Komatsu, K., Namba, T., and Kadota, S., Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu. Biol. Pharm. Bull., 22, 157-161 (1999) https://doi.org/10.1248/bpb.22.157
  5. Fan, W., Tezuka, Y., Ni, K. M, and Kadota, S., Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis. Chem. Pharm. Bull., 49, 396-401 (2001) https://doi.org/10.1248/cpb.49.396
  6. Kirby, A. J. and Schmidt, R. J., The antioxidant activity of Chinese herbs for eczema and of placebo herbs - I. J. Ethnopharmacol., 56, 103-108 (1997) https://doi.org/10.1016/S0378-8741(97)01510-9
  7. Houghton, P. J., Ethnopharmacology of some Buddleia species. J. Ethnopharmacol., 11, 293-308 (1984) https://doi.org/10.1016/0378-8741(84)90075-8
  8. Houghton, P. J., Woldemariam, T. Z., Candau, M., Barnardo, A., Khen-Alafun, O., and Shangxiao, L., Buddlejone, a diterpene from Buddleja albiflora. Phytochemistry, 42, 485-488 (1996) https://doi.org/10.1016/0031-9422(96)00001-5
  9. Jahn, B., Martin, E., Stueben, A., and Bhakdi, S., Susceptibility testing of Candida albicans and Aspergillus species by a simple microtiter menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. J. Clin. Microbiol., 33, 661-667 (1995)
  10. Kim, H. J., Woo, E.-R., Shin, C.-G., Hwang, D. J., Park, H., and Lee, Y. S., HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum. Arch. Pham. Res., 24, 286-291 (2001) https://doi.org/10.1007/BF02975093
  11. Liao, Y.-H., Houghton, P. J., and Hoult, J. R. S., Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J. Nat. Prod., 62, 1241-1245 (1999) https://doi.org/10.1021/np990092+
  12. Matsuda H., Cai, H., Kubo M., Tosa H., and Inuma, M., Study on anti-cataract drugs from natural sources. II. Effects on Buddlejae Flos on in vitro aldose reductase activity. Biol. Pharm. Bull., 18, 462-466 (1995)
  13. Mensah, A. Y., Houghton, P. J., Bloomfield S., Vlietinck, A., and Berghe, D. V., Known and novel terpene from Buddleja globosa displaying selective antifungal activity against dermatophytes. J. Nat. Prod., 63, 1210-1213 (2000) https://doi.org/10.1021/np0001023
  14. Pardo, F., Perich, F., Villarroel, L., and Torres R., Isolation of verbascoside, an antimicrobial constituents of Buddleja globosa leaves. J. Ethnopharmacol., 39, 221-222 (1993) https://doi.org/10.1016/0378-8741(93)90041-3
  15. Pietta, P-G., Flavonoids as antioxidants. J. Nat. Prod., 63, 1035-1042 (2000) https://doi.org/10.1021/np9904509
  16. Zimin, L. and Zhongjian, J., Phenylpropanoid and iridoid glycosides from Pedicularis strata. Phytochemistry, 30, 1341-1344 (1991) https://doi.org/10.1016/S0031-9422(00)95234-8