Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antibacterial Coumarins from Angelica gigas Roots

  • Lee, Sanghyun (Natural Products Research Institute, Seoul National University) ;
  • Shin, Dong-Sun (Natural Products Research Institute, Seoul National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute, Seoul National University) ;
  • Oh, Ki-Bong (Natural Products Research Institute, Seoul National University, Graduate School of Agricultural Biotechnology, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 2003.06.01
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Abstract

Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and $12.5{\;}{\mu}g/mL$, respectively.

Keywords

References

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