Archives of Pharmacal Research

  • 제26권2호
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  • Pages.147-150
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  • 2003
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan

  • Mar, Woongchon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Lee, Hyun-Tai (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Je, Kang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Choi, Hye-Young (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
  • 발행 : 2003.02.01
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초록

To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.

키워드

참고문헌

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