Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Effect of Artemisia Capillaris Crude Juice Extract on $CCl_4$ Induced Liver Damage in Dogs

인진쑥이 사염화탄소 투여로 유발된 개의 간 손상 회복에 미치는 영향

  • 이우열 (경북대학교 수의과대학) ;
  • 이성동 (경북대학교 수의과대학) ;
  • 손상익 (경북대학교 수의과대학) ;
  • 장혜숙 (일본 북해도대학 수의학과) ;
  • 김영홍 (경북대학교 수의과대학) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 엄기동 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학) ;
  • 박승춘 (경북대학교 수의과대학)
  • Published : 2003.09.01
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Abstract

Artemisia is a major edible vegetable in Korea and it has traditionally been used as a herbal medicine for the treatment of coughing, abdominal pain, indigestion, bleeding, jaundice, chronic liver disease and diabetes. However the biological and pharmacological actions of the herb have not been studied well. Recently it is known to possess antibacterial, antihelmintic and antifertility activities. But the effect of Artemisia capillaris extract on carbon tetrachloride($CCl_4$) induced liver damage in dogs have not been reported yet. This study was designed to investigate the effect .of Artemisia capillaris crude juice extract on $CCl_4$ induced liver damage in dogs. 30 clinically healthy dogs were divided into 2 groups: crude Artemisia capillaris juice treated group(CEC group) and carbon tetrachloride($CCl_4$) administerd group. The results are as follows: I. The degree of increase in AST activity and ALT activity in CEC group was lower than that in $CCl_4$ group and the recovery in CEC group was faster than that in $CCl_4$ group. 2. Changes of ALP concentration in CEC group were significant(P < 0.05) but changes of Total-bilirubin concentration were not significant(P < 0.05) in both groups. 3. The recovery of GGT concentration in CEC group was faster than that in $CCl_4$ group. 4. Hematological changes other than MCHC were significant(P < 0.05) in CEC group only and changes of GSH and Met-Hb concentration were significant(P < 0.05) in $CCl_4$ group.

Keywords

References

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