한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제31권3호
  • /
  • Pages.292-296
  • /
  • 2003
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Chromobacterium violaceum YK 391의 세포내 Cytosine Deaminnse와 5-Fluorocytosine의 병용사용이 치아우식 원인세균에 대한 항균성의 발현

Revelation of Antibacterial Effect Against Cariogenic Bacteria in Combination with 5-Fluorocytosine and Cytosine Deaminase from Chromobacterium violaceum YK 391.

  • 김정 (수원여자대학 치위생과) ;
  • 정혁준 (계명대학교 자연과학대학 미생물학과) ;
  • 유대식 (계명대학교 자연과학대학 미생물학과)
  • Kim, Jung (Department of Dental Hygiene, Suwon Women's College) ;
  • Jung, Hyuk-Jun (Department of Microbiology, Keimyung University) ;
  • Yoo, Dae-Sik (Department of Microbiology, Keimyung University)
  • 발행 : 2003.09.01
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초록

The antibacterial effect against cariogenic bacteria was evaluated in combination of 5-FC and intracellular cytosine deaminase from Chromobacterium violaceum YK 391. While S. mutans, L. parabuchneri and A. naeslundii showed antibacterial effect against 10 mM of 5-FU, S. intermedius, S. mitis, S. agalactiae, L. lactis, A. israelii, A. viscosus don't caused antibacterial effect. The addition of the cytosine deaminase and 10 mM of 5-FC to S. mutans, S. sanguis, L. brevis, L. parabuchneri, L. oris and A. naeslundii caused weakly antibacterial effect. S. sanguis caused weakly antibacterial effect against 10 mM of 5-FC. These results suggested that combination of the cytosine deaminase and 5-FC was showed the possibility to precautionary measures of dental caries.

키워드

참고문헌

  1. J. Med. Chem. v.26 Plasmin-activated prodrugs for cancer chemotherapy. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard Chakravarty,P.K.;P.L.Carl;M.J.Weber;J.A.Katzenellenbogen https://doi.org/10.1021/jm00359a003
  2. Biochem. Pharmacol. v.27 Mode of action of 5-fluorocytosine Diasio,R.B.;J.E.Bennett;C.E.Myers https://doi.org/10.1016/0006-2952(78)90507-5
  3. Antimicrob. Agents Chemother v.14 Evidence for conversion of 5-fluorocytosine to 5-fluorouracil in humans: Possible factor in 5-fluorocytosine clinical toxicity Diasio,R.B.;B.E.Lakings;J.E.Bennett https://doi.org/10.1128/AAC.14.6.903
  4. J. Dent. Res. v.12 Studies of the cause and nature of dental caries Enright,J.J.;H.E.Friesell;M.O.Treschen https://doi.org/10.1177/00220345320120050701
  5. J.Clin. Microbiol. v.1 Increased selectivity mitis-salivarious agar cantaining polymyxin Fitzgerald,R.J.;B.O.Adams
  6. Arch. Oral Biol. v.13 Synthesis of insoluble dextran and its signification in the formation of gelatins deposits by plaque-forming Streptococci Gibbons,R.J.;M.Nygaard https://doi.org/10.1016/0003-9969(68)90081-2
  7. Arch. Oral Biol. v.18 A selective medium for Streptococcus mutans Gold,O.G.;H.V.Jordan;J.van Houte https://doi.org/10.1016/0003-9969(73)90109-X
  8. Arch. Oral Biol. v.19 Identification of Streptococcus mutans colonies by mannitol-dependent tetrazolium reduction Gold,O.G.;H.V.Jordan;J.van Houte
  9. Ann. Arbor. Mich. v.6 Chemotherpeutic activity of 5-fluorocytosine. In : Antimicrobial Agents and Chemotherapy Grunberg,E.;E.Titsworth;M.Bennett
  10. Z. Biol. v.79 ber das verhalten von pyrimidinderivaten in den organismen. Einfluss von hefe auf pyrimidinderivate Hahn,A.;W.Lintzel
  11. Microbial. Rev. v.44 Biology, immunology and cariogenicity of Streptococcus mutans Hamada,S.;Slade,H.D.
  12. Brit. Dent. J. v.162 Chlorohexide gluconate mouth wash in the management minor aphthous ulceration Hunter,L.;M.Addy https://doi.org/10.1038/sj.bdj.4806042
  13. Anti-Cancer Drug Des. v.2 Hypoxic cells as specific drug targets for chemotheraphy Kennedy,K.A.
  14. Cancer Immunol. Immunother v.31 Antibody-penicillin-V-amidase conjugates kill antigen-positive tumor cells when combined with doxorubicin phenoxyacetamide Kerr,D.E.;P.D.Senter;W.V.Burnett;D.L.Hirschberg;I.Hellstrom;K.E.Hellstrom https://doi.org/10.1007/BF01789169
  15. Korean J. Biotechnol. Bioeng v.13 Revelation of antitumor effect in combination with 5-Fluorocytosine and extracellular cytosine deaminase Kim,T.H.;J.Kim;T.S.Yu
  16. J. Microbiol. Biotechnol. v.13 Purification and some properties of intracelluar cytosine deaminase from Chromobacterium violaceum YK 391 Kim,J.;H.S.Kim;T.S.Yu
  17. Dental pathology. ed. Kumoonsa Kim,Y.K.
  18. Biochem. Pharmac v.15 The metabolism of 5-fluorocytosine-$2^{14}$C and of cytosine-$^{14}C$in the rat and the disposition on 5-fluorocytosine-$2^{14}$C in man Koechlin,B.A.;F.Rubio;S.Palmer;T.Gabriel;R.Duschinsky https://doi.org/10.1016/0006-2952(66)90254-1
  19. Microbial., Rev. v.12 Role of Streptococcus mutans in human dental decay Loesche,W.J.
  20. Dental Microbiology Dental caries Menaker,L.;J.R.Mcghee;Mergenhagen,S.E.(ed.)
  21. Mikroorganismen der mundohle Miller,W.D.
  22. Agric. Biol. Chem. v.46 The structure of ribocitrin and its structure-activity relationship in the inhibition of dextransucrase of S. mutans E 49 Okami,Y.;O.Takashi;O.Yashiro https://doi.org/10.1271/bbb1961.46.2449
  23. Handbook of Microbiological Media Ronald,M.A.;Lawrence,C.P.(ed.)
  24. Agr. Biol. Chem. v.39 Purification of cytosine deaminase from Serratia marcescens Sakai,T.;T.S.Yu;H.Tabe;S.Omata https://doi.org/10.1271/bbb1961.39.1623
  25. Agr. Biol. Chem. v.39 Purification of cytosine deaminase from Pseudomonas aureofaciens Sakai,T.;T.S.Yu;K.Taniguchi;S.Omata https://doi.org/10.1271/bbb1961.39.2015
  26. Kor. J. Appl. Microbiol. Biotechnol. v.25 Isolation and identification of bacterium producing extracelluar cytosine deaminase Yu,T.S.;T.H.Kim