Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Combined Repeated Dose and Reproductive/Developmental Toxicities of Benzoyl Peroxide

Benzoyl Peroxide의 반복투여 독성과 생식 및 발생독성

  • 송상환 (국립환경연구원 환경위해성연구부) ;
  • 김수현 (국립환경연구원 환경위해성연구부) ;
  • 배희경 (국립환경연구원 환경위해성연구부) ;
  • 김미경 (국립환경연구원 환경위해성연구부) ;
  • 구현주 (국립환경연구원 환경위해성연구부) ;
  • 박광식 (동덕여자대학교 약학대학) ;
  • 이상균 (LG 생명과학기술연구원) ;
  • 박중훈 (LG 생명과학기술연구원) ;
  • 최은실 (LG 생명과학기술연구원)
  • Published : 2003.06.01
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Abstract

This study was carried out to assess the combined repeated dose, reproduction and developmental toxicities of benzoyl peroxide for OECD SIDS (Screening Information Data Set) program. Male and female Sprague-Dawley rats were exposed to benzoyl peroxide at dose levels of 0, 250, 500 and 1,000 mg/kg/day for 29 days for males and for 41-51 days for females. No deaths were found in all animals including control group during exposure period. No hematological effects attributable to benzoyl peroxide were observed in all treated groups. Significant decrease in the weight of testes and epididymis were observed in males at 1,000 mg/kg/day. In females at 1,000 mg/kg/day, slight histopathological effects in uterus such as epithelial vacuolation or hyperplasia were observed. No treatment-related changes in precoital time and rate of copulation, fertility and gestation period were noted in all treated groups. There was no evidence of teratogenic effect of benzoyl peroxide, but body weight of pups at 1,000 mg/kg/day was significantly decreased. NOAEL for combined repeated dose and reproduction/developmental toxicity was 500 mg/kg/day.

Keywords

References

  1. 국내 화학물질 유통량 조사 현황 국립환경연구원
  2. 變異原性と毒性 v.3 食品添加物の變異原性試驗成績 石館基;吉川邦衛;祖父尼俊雄
  3. 유해화학물질관리기본계획 환경부
  4. Contact Dermatitis v.35 An interlaboratory evaluation of the buehler test for the identification and classification of skin sensitizers Basketter,D.A.;Gerberick,G.F. https://doi.org/10.1111/j.1600-0536.1996.tb02332.x
  5. Mutagenesis v.13 The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxide Dillon,D.;Combes,R.;Zeiger,E. https://doi.org/10.1093/mutage/13.1.19
  6. Annu. Rep.Tokyo Metro. Res. Lab. P.H. v.38 Mutagenicity test of food additives with Salmonella typhimurium TA 97 and TA 102(II) Fujita,H.;Sasaki,M.
  7. Proc. Amer. Assoc. Cancer Res. v.34 Doseresponse of benzoyl peroxide hyperplastic, promoter and possible complete carcinogenic activities Gimenez-Conti,I.B.;Oubari,D.;Slaga,T.J.
  8. Contact Dermatitis v.13 Allergic and irritant potential of benzoyl peroxide Haustein,U.F.;Tegetmeyer,L.;Ziegler,V. https://doi.org/10.1111/j.1600-0536.1985.tb02559.x
  9. J. Toxicol. Environ. Health v.53 Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay; an interlaboratory evaluation Kimber,I.;Hilton,J.;Deaman,R.J.;Gerberick,G.F.;Ryan,C.A.;Basketter,D.A.;Lea,L.;House,R.V.;Ladics,G.S.;Loveless,S.E.;Hastings,K.L. https://doi.org/10.1080/009841098159141
  10. Cancer Letters v.24 Studies on the promoting and complete carcinogenic activities of some oxidizing chemicals in skin carcinogenesis Kurokawa,Y.;Takamura,N.;Matsushima,Y.;Imazawa,T.;Hayashi,Y. https://doi.org/10.1016/0304-3835(84)90026-0
  11. Occupational Exposure to Benzoyl Peroxide Criteria for Recommended Standard National Institute for Occupational Safety and Health(NIOSH)
  12. Cancer Research v.46 no.6 Enhanced malignant progression of mouse skin tumours by the free-radical generator benzoyl peroxide O'Connell,J.F.;Klein-Szanto,A.J.P.;DiGiovanni,D.M.;Fries,J.W.;Slaga,T.J.
  13. Manual for Investigation of HPV Chemicals OECD Secretariat
  14. Fd Cosmet. Toxicol. v.2 Study of the biological effects of benzoyl peroxide Sharratt,M.;Frazer,A.C.;Forbes,O.C. https://doi.org/10.1016/S0015-6264(64)80351-5
  15. Science v.213 Skin tumour-promoting activity of benzoyl peroxide, a widely used free radical-generating compound Slaga,T.J.;Klein-Szanto,A.J.P.;Triplett,L,L,I.;Yotti,L.P.;Trosko,J.E. https://doi.org/10.1126/science.6791284
  16. Fundam. Appl. Toxicol. v.18 Combined repeat dose and reproductive/developmental toxicity screening test (OECD): familiarization using cyclophosphamide Tanaka,S.;Kawashima,K.;Naito,K.;Usami,M.;Nakadate,M.;Imaide,K.;Takahashi,M.;Hayashi,Y.;Kurokawa,Y.;Tobe,M. https://doi.org/10.1016/0272-0590(92)90199-R
  17. Acute oral toxicity test in male albino rats Wazeter,F.X.;Goldenthal,E.
  18. Acute Inhalation to Rats Wazeter,F.X.;Goldenthal,E.
  19. Environ. Mol. Mutagen. v.11 no.12 Salmonella mutagenicity tests: IV. results from the testing of 300 chemicals Zeiger,E.;Anderson,B.;Haworth,S.;Lawlor,T.;Mortelmans,K. https://doi.org/10.1002/em.2850110602