Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats

염산 DDB-S가 랫드의 생식독성에 미치는 영향에 관한 연구

  • Kim, Hyun-Woo (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Park, Jin-Hong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Moon, Seo-Hyun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Eu, Gook-Jong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Hwa (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Joon-Seong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Park, Jong-Ha (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Cho, Hyun-Sun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Ka-Mi (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Hwang, Seong-Hee (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University) ;
  • Kim, Pan-Gyi (Laboratory of Environmental Health, College of National Science, Yongin University) ;
  • Moon, Jeon-Ok (Laboratory of Pharmaceutics, College of Pharmacy, Pusan National University) ;
  • Lee, Chi-Ho (Laboratory of Pharmaceutics, College of Pharmacy, Pusan National University) ;
  • Cho, Maing-Haing (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
  • 김현우 (서울대학교 수의과대학) ;
  • 박진홍 (서울대학교 수의과대학) ;
  • 문서현 (서울대학교 수의과대학) ;
  • 유국종 (서울대학교 수의과대학) ;
  • 김화 (서울대학교 수의과대학) ;
  • 김준성 (서울대학교 수의과대학) ;
  • 박종하 (서울대학교 수의과대학) ;
  • 조현선 (서울대학교 수의과대학) ;
  • 강가미 (서울대학교 수의과대학) ;
  • 황성희 (서울대학교 수의과대학) ;
  • 김판기 (용인대학교 자연과학대학) ;
  • 문전옥 (부산대학교 약학대학) ;
  • 이치호 (부산대학교 약학대학) ;
  • 조명행 (서울대학교 수의과대학)
  • Published : 2003.03.01
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Abstract

A teratogenic study of dimethyl dimethoxy biphenylate derivative (DDB-S) was carried out on Sprague-Dawley rats. DDB-S dissolved in saline was administered to male and female rats by intravenously injection at daily doses of 50 mg/kg, 75 mg/kg, and 100 mg/kg. A half of dams were sacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development. And the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive function of F1 offsprings were examined. There was no treatment-related difference in body weight, food consumption and necropsy findings of dams. No gross, skeletal and visceral abnormalities was observed in F1 fetuses from dams treated with DDB-S. F1 offsprings did not show any treatment-related difference in growth, reflex, behaviour and reproductive performance. At caesarean section of F1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion, DDB-S did not show any potential teratogenic effect in rats.

Keywords

References

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