Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Transformation of Ginsenosides to Compound K(IH-901) by Lactic Acid Bacteria of Human Intestine

  • Bae, Eun-Ah (Department of Food and Nutrition, Kyung-Hee University) ;
  • Kim, Na-Young (Department of Food and Nutrition, Kyung-Hee University) ;
  • Han, Myung-Joo (Department of Food and Nutrition, Kyung-Hee University) ;
  • Choo, Min-Kyung (College of Pharmacy Kyung-Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy and East-West Mecical Research Institute, Kyung Hee University)
  • Published : 2003.02.01
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Abstract

When ginsenosides Rbl, Rb2, and Rc were anaerobically incubated with commercial and human intestinal lactic acid bacteria, most commercial lactic acid bacteria did not metabolize these ginsenosides to compound K. However, lactic acid bacteria, B. minimum KK-1, Bifidobacterium cholerium KK-2, and B. cuniculi K-513, isolated from human intestinal microflora transformed these ginsensosides to compound K. When the bacterial mixtures of commercial lactic acid bacteria were incubated with these ginsenosides, these compounds were not transfformed to compound K. However, when Bzfidobacterium KK-1 and KX-2 were miked, these ginsenosides were synergistically transformed to compound K. When water extract of ginseng was incubated with these mixed bifidobacteria, compound K was potently produced. Therefore, it is suggested that, if ginseng with these mixed bifidobacteria is fermented, compound K-enforced ginseng materials could be produced that show cytotoxicity against tumor cell lines.

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References

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