Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Effects of ChungSangSaWhaTang on The Arteral Contraction in Rabbit

청상사화탕(淸上瀉火湯)이 토끼의 수축혈관에 미치는 영향

  • Jeon, Sung-Bai (Dept. of Internal Medicine, College of Oriental Medicine, Semyung Univ.) ;
  • Kim, Ee-Hwa (Dept. of Meridian & Acupoint, College of Oriental Medicine, Semyung Univ.) ;
  • Nam, Chang-Gyu (Dept. of Internal Medicine, College of Oriental Medicine, Semyung Univ.)
  • 전성배 (세명대학교 한의과대학 내과학교실) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 남창규 (세명대학교 한의과대학 내과학교실)
  • Published : 2003.12.30
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Abstract

This study was undertaken to define the effect of ChungSangSaWhaTang on the norepinephrine-induced arterial contraction and the mechanism of ChungSangSaWhaTang-induced relaxation. In order to investigate the effect of ChungSangSaWhaTang on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of ChungSangSaWhaTang-induced relaxation, ChungSangSaWhaTang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, $N_{\omega}$-nitro-L-arginine, or tetraethylammonium chloride. ChungSangSaWhaTang relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, ChungSangSaWhaTang-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by ChungSangSaWhaTang was decreased by the pretreatment of $N_{\omega}$-nitro-L-arginine, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. We suggest that ChungSangSaWhaTang may inhibit agonist-induced contraction through the formation of nitric oxide in the vascular endothelial cells.

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