Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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The Potential of Cnidium officinale Makino as the Component of Gamgungtang to Induce the phase II Enzyme in vivo

감궁탕 처방 중 천궁의 생체에서 Phase II 효소 유도 효과

  • Han Sang-Hun (Dept. of Merdian & Acupoint, College of Oriental Medicine, Dongguk University) ;
  • Shon Yun-Hee (Dept. of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University) ;
  • Kim Hyuck (Dept. of Merdian & Acupoint, College of Oriental Medicine, Dongguk University) ;
  • Lee Hee-Soon (Dept. of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University) ;
  • Park In-Kyung (Faculty of Food Science and Industrial Technology, Catholic University of Deagu) ;
  • Nam Kyung-Soo (Dept. of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk Universtiy) ;
  • Kim Cheorl-Ho (Dept. of Biochemistry, College of Oriental Medicine, Dongguk University) ;
  • Lim Jong-Kook (Dept. of Merdian & Acupoint, College of Oriental Medicine, Dongguk University)
  • 한상훈 (동국대학교 한의과대학 경혈학교실) ;
  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 김혁 (동국대학교 한의과대학 경혈학교실) ;
  • 이희순 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 박인경 (대구카톨릭대학교 식품산업학부) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 김철호 (동국대학교 한의과대학 생화학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실)
  • Published : 2003.03.27
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Abstract

The activity of phase II enzyme in the liver of mice was examined following the application of Cnidium officinale Makino aqua-acupuncture solution (COMAS). The application of COMAS $CV_{12}$ to mice for 7 days increased quinone reductase(QR) activity. The glutathione S-transferase(GST) activity was also increased with COMAS. A greater increase was observed in the glutathione(GSH) levels than in the QR and GST activities.

천궁약침액을 7일간 중완혈, 간수혈 및 임의혈에 투여한 후 마우스의 간에서 유도되는 phase II enzyme 유도 효과를 살펴본 결과 마우스의 간 조직에서 Phase II 효소의 활성이 증가된 것으로 보아 천궁약침액은 외부물질이나 대사산물에 의해 일어날 수 있는 암발생 억제 효과가 있는 것으로 사료된다.

Keywords

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