Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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FUSION OF THE PLAG1 AND CTNNB1 GENES IN PLEOMORPHIC ADENOMA OF THE SALIVARY GLANDS

타액선 다형성 선종에서의 PLAG1과 CTNNB1 유전자 융합

  • Kim, Jae-Jin (Department of Oral and Maxillofacial Surgery, Chungnam National University Hospital) ;
  • Kim, Eun-Seok (Department of Oral and Maxillofacial Surgery, Chungnam National University Hospital) ;
  • Ko, Seung-O (Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Kim, Hyo-Bun (Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Cho, Nam-Pyo (Institute of Oral Bioscience, School of Dentistry, Chonbuk National University)
  • 김재진 (충남대학교 병원 구강악안면외과) ;
  • 김은석 (충남대학교 병원 구강악안면외과) ;
  • 고승오 (전북대학교 치과대학 구강생체과학연구소) ;
  • 김효분 (전북대학교 치과대학 구강생체과학연구소) ;
  • 조남표 (전북대학교 치과대학 구강생체과학연구소)
  • Published : 2003.08.31
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Abstract

The pleomorphic adenoma is the most common neoplasm involving both the major and minor salivary glands. It is a benign, slowgrowing tumor, but local recurrences can occur. The pleomorphic adenoma gene 1 (PLAG1), which is a novel zinc finger gene, is frequently activated by reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. This experimental study was preformed to observe the translocation patterns between PLAG1 gene and the three translocation partner genes. We also have analyzed the presence of PLAG1 transcripts by RT-PCR. CTNNB1/PLAG1 gene fusion was observed in three of nine pleomorphic adnomas. However, LIFR/PLAG1 and SII/PLAG1 gene fusions were not detectable. All of three gene fusions was not detectable in one Warthin's tumor and three inflammatory salivary gland tissues. PLAG1 transcripts were expressed in all inflammatory salivary gland tissues and tumors except for three pleomorphic adenomas. Of particular one pleomorphic adenoma showing CTNNB1/PLAG1 gene fusion did not express PLAG1 transcipt. Our data indicate that gene fusion involving PLAG1 is a frequent event in pleomorphic adenoma, but correlation between gene fusion involving PLAG1 and PLAG1 transcription is not definite.

Keywords

References

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