식용 식물자원으로부터 활성물질의 탐색-V. -상추(Lactuca sativa L.)의 ACAT 억제 Diterpenoid, Phytol-

Development of Biologically Active Compound from Edible Plant Sources -V. -Phytol, ACAT (Acyl-CoA: Cholesterol Acyltransferase) Inhibitory Diterpenoid From the Leaves of Lactuca sativa L.-

  • 장태오 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 방면호 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 송명종 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 홍윤희 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 김지영 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 정대균 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 배동근 (안양대학교 식품영양학과) ;
  • 권병목 (한국생명공학연구원) ;
  • 김영국 (한국생명공학연구원) ;
  • 이현선 (한국생명공학연구원) ;
  • 김인호 (한국식품개발연구원) ;
  • 백남인 (경희대학교 생명공학원 및 식물대사연구센터)
  • Jang, Tae-O (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Bang, Myun-Ho (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Song, Myoung-Chong (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Hong, Yoon-Hee (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Kim, Ji-Young (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Chung, Dae-Kyun (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Pai, Tong-Kun (Dept. of Food & Nutrition, Anyang Univ.) ;
  • Kwon, Byung-Mok (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Kuk (Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, In-Ho (Korea Food Research Institute) ;
  • Baek, Nam-Ln (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
  • 발행 : 2003.02.28

초록

키워드

참고문헌

  1. Jung, E. B. and Shin, M. K. (1990) In Hyang Yak Dae Sa Jun Young Lim Sa, Seoul, Korea, PP. 1060
  2. Mahmoud, Z. R, Kassem, F. R, Abdel-Salam, N. A. and Zdero,C, (1986) Sesquiterpene lactones from Lactuca sativa.Phytochemistry 25, 747-748 https://doi.org/10.1016/0031-9422(86)88039-6
  3. Izawa K., Nagai M. and hioue T. (1973) Thterpene acids and bergenin in Pettoboykinia watanabei and Boykinia lycoctonifolia. Phytochemistry 12, 1508 https://doi.org/10.1016/0031-9422(73)80604-1
  4. Bikram, S., Pawan, K. A. and Raghunath, S. T. (1991) Isolationof trans-phytoI from Phyllanthus niriri. Chem. Pharm. Butt. 57,98
  5. Brown, G. D. (1994) Phytene-1,2diol from Artemisia annua. Phytochemislry 36, 1553-1554 https://doi.org/10.1016/S0031-9422(00)89762-9
  6. Hahn, J.-T, Kim, H.-Y, Park, Y.-D., Lee, Y.-H., Lee, K.-R.,Kwon, B.-M. and Baek, N.-I. (2002) Acenphyllic acid A, a new ACAT inhibitory tnierpenoid, from Aceriphyllum mssii.PIanta Medica 68, 556-558 https://doi.org/10.1055/s-2002-32562
  7. Lawson, T., Nunnally, J., Walker, B., Brensnick, E., Wheeler, D. and Wheeler, M. (1989) Isolation of compounds with antimutagenic activity from Savoy chieftain cabbage. J. Agri.Food Chem. 37, 1363-1367 https://doi.org/10.1021/jf00089a034
  8. Cho, Y. H., Ahn, S. J., Park, K. Y, Yoo, M. A. and Lee, W. H. (1993) Effects of phytol on the mutagenicity of UV and EMS in Salmonella and Drosophila mutation assaying systems. Environ. Mutag. Carcin. 13, 92-100
  9. Kim, K. H., Chang, M. W., Park, K. Y., Rhee, S. H., Rhew, T.H. and Sunwoo, Y. I. (1993) Antitumor activity of phytolidentified from perilla leaf and its augmentative effect on cellular immune response. Korean J. Nutr. 26, 379-389
  10. Lee, K. L., Lee, S. H. and Park, K. Y. (1999) Anticancer activity of phytol and eicosatrienoic acid identified from peiilla leaves. J. Korean Soc. Food Sci. Nutr. 28, 1107-1112