생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
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상심자의 모노아민산화효소 저해활성

The Inhibitory Activity on Monoamine Oxidase of the Fruit of Morus alba

  • 황금희 ((주) STC 생명과학연구원) ;
  • 송임 ((주) STC 생명과학연구원)
  • 발행 : 2003.06.30
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초록

We examined the inhibitory activities against monoamine oxidase (MAO) of Morus alba in vitro and in vivo methods. Methanolic extract of M. alba showed significantly inhibitory activities on MAO-A and MAO-B that were prepared from rat brain and liver in vitro. The inhibitory activities were measured by serotonin and benzylamine as substrates, respectively. MAO-A and MAO-B activities were potently inhibited by ethylacetate extracts of M. alba in vitro tests. Those activities in vivo tests have different tendency each other. MAO-A activity was increased by the oral administration of methanolic extract of M. Alba, while, MAO-B activity was decreased. Consequently, we can suggest that M. alba may have the effects on the inhibitory activities against MAO both in vitro and in vivo.

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참고문헌

  1. 강봉수(2000) 본초학. 60. 영림사. 서울
  2. Namba, T. (1993). The Encyclopedia of Wakan-Yaku with Color Pictures Vol. 1. 82-83. Hoikusha, Osaka
  3. 동의보감국역위원회(2000) 동의보감, 1271. 남산당, 서울
  4. Cooper, J. R., Bloom, F. E. and Roth, R. H. (1996) The Biochemical Basis of Neuropharmacology. Oxford university press. NY
  5. FeIner, A. E. and Waldmeier, P. C. (1979) Cumulative effects of irreversible MAO inhibitors in vivo. Biochem. Pharmac 28: 995-1002 https://doi.org/10.1016/0006-2952(79)90293-4
  6. Hwang, K. H. and Lim, S. H. (2003) Studies on monoamine .oxidase inhibitory activities of Korean medicinal plants classified to cold drugs by the theory of KIMI. Food Science and Biotechnology. 12(3): in press
  7. Hwang, K. H., Kim, I. R. and Han, Y .N. (1999) Effects of cold and hot drugs on the activity of monoamine oxidase. Kor. J. Pharmacogn. 30: 145-150
  8. McEwen, C. M., Cohen, J. R. and Cohen, J. D. (1963) An amine oxidase in normal human serum. J. Lab. Clin. Med. 62: 766-776
  9. SAS: SAS User's Guide, Statistics (1988) SAS Institute Inc., Cary, NC
  10. Daniel, M. B. and Stuart, J. E. (1990) Protein Methods. Wiley-Liss, NY
  11. Hwang, K. H., Ma, J. Y and Kim, J. R. (1999) The Studies on the Theory of KIMI by the Activity of Monoamine Oxidase. Kor. J. Herbology. 14(1): 1-14