Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Arachidonic acid Cascade Related Enzymes Inhibitors from Korean Indigenous Plants(1)

한국 자생식물로부터 아라키돈산 대사계 효소 저해제 검색(1)

  • Moon, Tae-Chul (College of Pharmacy, Yeungnam University) ;
  • Jung, Hye-Jin (College of Pharmacy, Yeungnam University) ;
  • Lee, Eun-Kyung (College of Pharmacy, Yeungnam University) ;
  • Park, Hae-Young (Depart. Food & Nutrition, Andong National University) ;
  • Jeon, Su-Jin (Depart. Food & Nutrition, Andong National University) ;
  • Son, Kun-Ho (Depart. Food & Nutrition, Andong National University) ;
  • Kim, Hyun-Pyo (College of Pharmacy, Kangwan National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Kang, Sam-Sik (Natural Products Res. Institute. Seoul National University) ;
  • Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy and Korea Institute of Oriental Pharmacy, Wonkwang University) ;
  • Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
  • Published : 2003.03.30
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Abstract

Arachidonic acid(AA), which is stored in membrane glycerophospholipids, is liberated by phospholipase $A_2(PLA_2)$ enzymes and is sequentially converted to cyclooxygenase (COX) and lipoxygenase (LOX) then to various bioactive prostaglandins (PGs,) and leukotrienes (LTs). In order to find the specific inhibitors of AA metabolism enzymes such as $PLA_2$, COX-2, 5-LO and lyso PAF acetyltransferase. 195 Korean indigenous plant extracts were evaluated for their inhibitory activity on $PGD_2,\;LTC_4$ production from cytokine-induced mouse bone marrow-derived mast cells (BMMC) and arachidonic acid released from phospholipid and PAF production from lyso PAF. From this screening procedure, methanol extract of eight plants such as Saururus chinensis, Aster tataricus, Chrysanthemum cinerariaefolium, Reynoutria japonica, Disocorea nipponica, Epimedium koreanum, impatiens textori, Veronica rotunda var. subintegra were found to inhibit production of inflammatory mediators in vitro assay system.

Keywords

References

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