Natural Product Sciences

  • 제9권3호
  • /
  • Pages.195-199
  • /
  • 2003
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Ethnopharmacological Evaluation of Peristrophe bicalyculata Nees. for Anti-inflammatory and Analgesic Activity

  • Rathi, Anshu (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research)) ;
  • Rao, Ch.V. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research)) ;
  • Khatoon, S. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research)) ;
  • Mehrotra, S. (Pharmacognosy and Ethnopharmacology Division National Botanical Research Institute, (Council of Scientific Industrial Research))
  • 발행 : 2003.09.01
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초록

The ethanolic (50% v/v) extracts of Peristrophe bicalyculata Nees. (Acanthaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. P. bicalyculata in doses of 50, 100 and 200 mg/kg caused a dose dependent inhibition of swelling caused by carrageenin equivalent to 12.25-24.49% protection and 16.62-39.44% in cotton pellet induced granuloma in rats. There was a significant increase in the tail-flick reaction time in mice (18.05-76.43% protection) and analgesy-meter induced pain in rats (14.49-56.85%) protection). The extract of P. bicalyculata resulted in an inhibition of stretching episodes and the protection range of 14.49-56.85% respectively in acetic acid induced writhing.

키워드

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