Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antitumor and Immunostimulating Activities of Acanthopanax sessiliflorus Fruits

  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University, College of Pharmacy, Seoul National University) ;
  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Ji, Jun (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Kim, Bak-Kwang (College of Pharmacy, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 2003.06.01
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Abstract

The antitumor and immunostimulating activities of Acanthopanax sessiliflorus fruits were investigated. Polysaccharide isolated from this plant, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume in mice inoculated with Sarcoma-180 tumor cells. Polysaccharide was also demonstrated to exhibit phagocytosis-enhancing activity as measured by the carbon clearance in mice. Polysaccharide, when administered i.p. at 50 and 100 mg/kg/day for 3 consecutive days, exhibited a significant RCtr/RCc [the rate of regression coefficient of the animals teated (RCtr) to that of the control (RCc)], being 1.44 (PI = 1), 1.52 (PI = 2) which was approximately the same with that of enhancement of phagocytosis, its potency as expressed by the regression coefficient ratio of zymosan (RCtr/RCc = 1.55, PI = 2), a typical phagocytosis enhancer. Polysaccharide also caused a significant increase in the acid phosphatase activity representing lysosomal enzymes in macrophages at 1-100 ig/ml in vitro in compliance with in vivo results. These results suggest that the antitumor activity of polysaccharide might be related to the immunostimulating function.

Keywords

References

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