Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-allergic Effect of Aqueous Extract of Stachys riederi var.japonica Miq.in vivo and in vitro

  • Published : 2003.03.01
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Abstract

The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) (SRAE) on the immediate-type allergic reactions was investigated. SRAE was found to exhibit a inhibitory activity on the compound 48/80-induced systemic anaphylaxis in mice. SRAE inhibited the plasma histamine release induced by compound 48/80 in mice. In addition, SRAE also inhibited the passive cutaneous anaphylaxis reaction induced by IgE/anti-IgE in mice. The effect of SRAE on the histamine release from rat peritoneal mast cells (RPMC) was studied. SRAE inhibited the histamine release induced by compound 48/80 in RPMC. To clarify the mechanism of these inhibiting reactions, we investigated the effects of SRAE on cyclic AMP (cAMP). The level of cAMP in human leukemia cell line, HMC-1, when SRAE (1 mg/ml) was added, significantly increased compared with that of basal cells. These results indicate that SRAE may be beneficial in the treatment of immediate-type allergic reaction.

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References

  1. Alber, G., Miller, L., Jelsema, C., Varin-Blank, N., and Metzger, H., Structure/function relationships in the mast cell high-affinity receptor for IgE (FcsRI): Role of cytoplasmic domains. J. Biol. Chem. 266, 22613-22620 (1991)
  2. Allansmith, M. R., Baird, R. S., Ross, R. N., Barney, N. P., and Bloch, K. J., Ocular anaphylaxis induced in the rat by topical application of compound 48/80. Dose response and time course study. Acta Ohpthalmol. 67, 145-153 (1989)
  3. Bae, K.H., The Medicinal Plants of Korea, Kyo-Hak Publishing Co. Ltd, Seoul, 2000, pp.447
  4. Baltzly, R., Buck, J. S., De Beer, E. J., and Webb, F. S., A family of long acting depressors. J. Am. Chem. Soc. 71, 1301-1305 (1949) https://doi.org/10.1021/ja01172a045
  5. Bueb, J. L., Mousli, M. C., Bronner, C, Rouot, B., and Landry, Y., Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. Mol. Pharmacol. 38, 816-822 (1990)
  6. Ennis, M., Pearce, F. L., and Weston, P. M., Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol. 70, 329-334 (1980) https://doi.org/10.1111/j.1476-5381.1980.tb07940.x
  7. Kanemoto, T. J., Kasugai, T., Yamatodani, A., Ushio, H., Mochizuki, T., Tohya, K., Kimura, M., Nishimura, M., and Kitamura, Y., Supernormal histamine release and normal cytotoxic activity of Biege rat mast cells with giant granules. Int. Arch. Allergy Immunol. 100, 99-106 (1993) https://doi.org/10.1159/000236395
  8. Katayama, S., Shionoya, H., and Ohtake, S., A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats. Microbiol. Immunol. 22, 89-101 (1978)
  9. Kim, H. M., and Lee, Y. M., Role of TGF-betal on the IgE-dependent anaphylaxis reaction. J. Immunol. 162, 4960-4965 (1999)
  10. Lagunoff, D., Martin, T. W., and Read, G., Agents that release histamine from mast cells. Annu. Rev. Pharmacol. Toxicol. 23, 331-351 (1983) https://doi.org/10.1146/annurev.pa.23.040183.001555
  11. Lau, H. Y., and Wan, S. P., Inhibition of compound 48/80 induced histamine release from mast cells by chloride channel blockers is affected by methods of drug preincubation. Inflamm. Res. 49, S2l-S22 (2000)
  12. Levi-Schaffer, F., Slovic, D., Armetti, L., Pickholtz, D., and Touitou, E., Activation and inhibition of mast cells degranulation affect there morphometric parameters. Life Sci. 66, PL283-PL290 (2000) https://doi.org/10.1016/S0024-3205(00)00538-5
  13. Makino, H., Saijo, T., Ashida, Y., Kuriki, H.H., and Maki, Y., Mechanism of action of an antiallergic agent: Amlexanox (AA-673), in inhibiting histamine release from mast cells. Int, Arch. Allergy Immunol. 82, 66-71 (1987) https://doi.org/10.1159/000234292
  14. Metzger, H., Alcaraz, G., Hohman, R., Kinet, J. P., Pribluda, V., and Quarto, R., The receptor with high affinity for immunoglobulin E. Annu. Rev. Immunol. 4, 419-470 (1986) https://doi.org/10.1146/annurev.iy.04.040186.002223
  15. Mousli, M. C., Bronner, C., Bockaert, J., Rouot, B., and Landry, Y., Interaction of substance P, compound 48/80 and mastoparan with $\alpha-subunit$ C-terminal of G protein. Immunol. Lett. 25, 355-358 (1990a) https://doi.org/10.1016/0165-2478(90)90207-7
  16. Mousli, M. C., Bronner, C., Landry, Y., Bockaert, J., and Rouot, B., Direct activation of GTP-binding regulatory proteins (G proteins) by substance P and compound 48/80. FEBS Lett. 259, 260-262 (1990b) https://doi.org/10.1016/0014-5793(90)80023-C
  17. Paton, W. D. M., Compound 48/80: A potent histamine liberator. Br. J. Pharmacol. 6, 499-508 (1951)
  18. Peachell, P. T., MacGlashan, D. W., Lichtenstein, L. M., and Schleimer, R. P., Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate. J Immunol. 140, 571-579 (1988)
  19. Petersen, L. J., Mosbech, H., and Skov, P., Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: Characterization of factors influencing histamine releasability. J. Allergy Clin. Immunol. 97, 672-679 (1996) https://doi.org/10.1016/S0091-6749(96)70313-5
  20. Segal, D. M., Taurog, J., and Metzger, H., Dirneric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc. Natl. Acad. Sci. 74, 2993-2997 (1977) https://doi.org/10.1073/pnas.74.7.2993
  21. Shin, H. Y., Yun, Y. B., Kim, J. Y., Moon, G., Shin, T. Y., Kim, H. S., and Kim, H. M., Inhibitory effect of mast cell-mediated acute and chronic allergic reactions by Dodutang. Immunopharmacol. Immunotoxicol. 24, 583-594 (2002) https://doi.org/10.1081/IPH-120016037
  22. Shin, T. Y., Park, J. H., and Kim, H.M., Effect of Cryptotympana atrata extract on compound 48/80-induced anaphylactic reactions. J. Ethnopharmacol. 66, 319-325 (1999) https://doi.org/10.1016/S0378-8741(98)00223-2
  23. Shin, T. Y., Kim, S. H., Lee, E. S., Eom, D.O., and Kim, H. M., Action of Rubus coreans extraction on systemic and local anaphylaxis. Phytothe. Res. 16, 508-513 (2002) https://doi.org/10.1002/ptr.925
  24. Shin, T. Y., and Lee, J. K., Effect of Phlomis umbrosa root on mast cell-dependent immediate-type allergic reactions by anal therapy. Immunopharmacol. Immunotoxicol. 25, 73-85 (2003) https://doi.org/10.1081/IPH-120018285
  25. Shore, P. A., Burkhalter, A., and Cohn, Y. H., A method for fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127, 182-186 (1959)
  26. Tasaka, K., Mio, M., and Okamoto, M., Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Allergy 56, 464-469 (1986)
  27. Wasserman, S. I., and Marquardt, D. L., Anaphylaxis in Allergy: Principles and Practice, C.V. Mosby, St Louis, 1988, pp. 1365
  28. Wershil, B. K., Mekori, Y A., Murakami, T., and Galli, S. J., $^{123}I-fibrin$ deposition in IgE-dependent immediate hypersensitivity reactions in mouse skin: Demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells. J. Immunol. 139, 2605-2614 (1987)
  29. Yurt, R. W., Leid, R. W., and Austen, K. F., Native heparin from rat peritoneal mast cells. J. Biol. Chem. 252, 518-521 (1977)