Journal of Sasang Constitutional Medicine (사상체질의학회지)
- Volume 15 Issue 2
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- Pages.137-150
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- 2003
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- 1226-4075(pISSN)
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- 2287-786X(eISSN)
Effects of Hyungbangjihwangtang Water Extract on Cultured Primary hippocampal Cell Damaged by Glucose Oxidase
형방지황탕(荊防地黃湯) 전탕액(煎湯液)이 산소자유기로 손상된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 영향
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Kim, Kyung-Yo
(Dept. of Oriental Medicine Graduate School of Won Kwang University)
;
- Bae, Young-Chun (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
- Lo, Hyun-Soo (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
- Kim, Jong-Gwan (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
- Han, Byung-Sam (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
- Gwon, Duk-Yun (Dept. of Oriental Medicine Graduate School of Won Kwang University) ;
- Choi, Yong-Seok (Dept. of Oriental Medicine Graduate School of Won Kwang University)
-
김경요
(원광대학교 한의과대학 사상체질과)
;
- 배영춘 (원광대학교 한의과대학 사상체질과) ;
- 노현수 (원광대학교 한의과대학 사상체질과) ;
- 김종관 (원광대학교 한의과대학 사상체질과) ;
- 한병삼 (원광대학교 한의과대학 사상체질과) ;
- 권덕윤 (원광대학교 한의과대학 사상체질과) ;
- 최용석 (원광대학교 한의과대학 사상체질과)
- Published : 2003.08.30
Abstract
The purpose of this study is to examine the toxic effects caused by glucose oxidase (GO) and the effects of Hyungbangjihwangtang (HJT) water extracts on the treatment of the toxic effects. For this purpose, experiments with the cultured hippocampal cells from new born mice were done. The results of these experiments were as follows. 1. GO decreased the survival rate of the cultured cells on MTT assay and NR assay. 2. HJT has the efficacy of decreasing the lipid peroxidation. 3. HJT has the efficacy of increasing the amount of neurofilaments. 4. HJT has the efficacy of decreasing the activation of protein kinase C(PKC). From the above results, it is concluded that HJT has marked efficacy as a treatment for the damages caused by the GO-mediated oxidative stress. Further clinical study of this pharmacological effects of H]T should be completed.
Keywords