Bulletin of the Korean Chemical Society

  • 제24권9호
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  • Pages.1303-1307
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  • 2003
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Characterization and Modification of Low Molecular Water-Soluble Chitosan for Pharmaceutical Application

  • Jang, Mi-Kyeong (Department of Polymer Science & Engineering, Sunchon National University) ;
  • Nah, Jae-Woon (Department of Polymer Science & Engineering, Sunchon National University)
  • 발행 : 2003.09.20
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초록

The low molecular water-soluble chitosan nanoparticles (LMWSC-NPs) were prepared, which was modified with hydrophilic and hydrophobic moieties to evaluate the potential for pharmaceutics application. The synthesis of LMWSC-NPs was identified by FT-IR and $^1H$-NMR spectra. Also, we measured the photon correlation spectroscopy (PCS), transmission electron microscope (TEM) and atomic force microscope (AFM) to investigate the characteristics and morphology of the LMWSC-NPs. At the PCS measurement, the more increase the number of substitutive group, the more decrease the positive charge of LMWSC-NP surface. From the results of TEM and AFM, spherical morphologies were observed, and their sizes were 30-150 nm. Resultantly, LMWSC-NPs prepared in this experiment will be expected as a suitable device for the drug targeting system.

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참고문헌

  1. Kreuter, J. J. Control. Rel. 1991, 16, 169. https://doi.org/10.1016/0168-3659(91)90040-K
  2. Allemann, E.; Gurny, R.; Doelker, E. Eur. J. Pharm. Biopharm.1993, 39, 173.
  3. Nah, J. W.; Jeong, Y. I.; Cho, C. S. J. Polym. Sci., Part B: Polym.Phys. 1998, 36, 415. https://doi.org/10.1002/(SICI)1099-0488(199802)36:3<415::AID-POLB3>3.0.CO;2-Q
  4. Lee, C. W. Korea Polymer Journal 2001, 9, 259.
  5. Kataoka, K.; Kwon, G. S.; Yokoyama, M.; Okano, T.; Sakurai, Y.J. Control. Rel. 1993, 24, 119. https://doi.org/10.1016/0168-3659(93)90172-2
  6. Cammas, S.; Kataoka, K. Macromol. Chem. Phys. 1995, 196,1899. https://doi.org/10.1002/macp.1995.021960609
  7. Khang, G.; Choi, M. K.; Rhee, J. M.; Lee, S. J.; Lee, H. B.;Iwasaki, Y.; Nakabayashi, N.; Ishihara, K. Korea Polymer Journal2001, 9, 107.
  8. Nah, J. W.; Jang, M. K. J. Polym. Sci., Part A: Polym. Chem. 2002,40, 3796. https://doi.org/10.1002/pola.10463
  9. Tatsuro, O.; Hidetoshi, N.; Yuichi, O. Polymer 1998, 39, 5181.
  10. Lee, K. Y.; Jo, W. H.; Kwon, I. C.; Kim, Y. H.; Jeong, S. Y.Langmuir 1998, 14, 2329. https://doi.org/10.1021/la970928d
  11. Hrkach, J. S.; Peracchia, M. T.; Domb, A.; Lotan, N.; Langer, L.Biomaterials 1997, 18, 27. https://doi.org/10.1016/S0142-9612(96)00077-4

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