Bulletin of the Korean Chemical Society

  • 제24권4호
  • /
  • Pages.473-478
  • /
  • 2003
  • /
  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Electron Impact Ionization Mass Spectra of 3-Substituted-2-hydroxy-4(3H)-quinazolinones

  • El Deen, I.M. (Faculty of Education, Suez Canal University) ;
  • Abd El Fattah, M.E. (Faculty of Science, Suez Canal University)
  • 발행 : 2003.04.20
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초록

3-Amino-2-hydroxy-4(3H)-quinazolinone (3) was prepared via condensation of 1 with hydrazine hydrate. Treatment of 3 with appropriate acid in $POCl_3$, ethyl chloroacetate and activated olefinic compounds in DMF yielded the corresponding 3-(substituted)amino-2-hydroxy-4(3H)-quinazolinones 4, 5 and 6. The electron impact ionization mass spectra of compounds 3 and 4 show a weak molecular ion peak and a base peak of m/z 146 resulting from a cleavage fragmentation. The compounds 5 and 6 give a characteristic fragmentation pattern with a very stable fragment of benzopyrazolone (m/z 132).

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참고문헌

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피인용 문헌

  1. Synthesis and mass spectral fragmentation patterns of some nitrogen heterocycles with antimicrobial activity vol.40, pp.2, 2014, https://doi.org/10.1007/s11164-012-1009-8