Bulletin of the Korean Chemical Society

  • 제24권5호
  • /
  • Pages.623-626
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  • 2003
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC

  • Paik, Seung-Uk (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Park, Myung-Kwang (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Jhun, Seong-Hoon (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Park, Heai-Ku (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Lee, Chun-Soo (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Cho, Bum-Rae (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Byun, Hong-Sik (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Choe, Seok-Burm (Faculty of Chemical & Materials Engineering, Keimyung University) ;
  • Suh, Seong-Il (Department of Microbiology, School of Medicine, Keimyung University)
  • 발행 : 2003.05.20
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초록

Nematophin and its analog incorporating tryptamine unit have been isolated and characterized from strain XRPC of a symbiotic bacterium Xenorhabdus nematophilus, which was newly isolated from Korean entomopathogenic nematodes. The stereoselective synthesis of these compounds was accomplished, and the relative configurations were determined. Nematophin exhibited potent antibacterial activities over several strains of methicillin-resistant S. aureus (MRSA) comparable to those of vancomycin.

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참고문헌

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피인용 문헌

  1. NRPS Substrate Promiscuity Diversifies the Xenematides vol.13, pp.19, 2011, https://doi.org/10.1021/ol2020237
  2. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines vol.15, pp.1, 2009, https://doi.org/10.3390/molecules15010068
  3. Isolation and Synthesis of Tryptamine Derivatives from a Symbiotic Bacterium Xenorhabdus nematophilus PC. vol.34, pp.45, 2003, https://doi.org/10.1002/chin.200345209
  4. Xenocyloin Derivatives from Liquid Cultures of Xenorhabdus bovienii SN52 vol.12, pp.12, 2003, https://doi.org/10.1177/1934578x1701201209