A Case of Churg-Strauss Syndrome Affecting Lung and Neuromuscular System

폐장 및 신경근계를 침범한 Churg-Strauss 증후군 1예

Churg-Strauss syndrome(CSS) is a systemic vascular disorder that has an unknown cause with multiorgan involvement and diverse presentations. The three main histologically distinct phases were necrotizing vasculitis, tissue eosinophilia and extravascular granulomas. A diagnosis of CSS can be made on four or more of the following six criteria : 1) asthma, 2) peripheral eosinophilia >10% on the differential leukocyte count, 3) mononeuropathy (including multiple) or polyneuropathy, 4) paranasal sinus abnormalities, 5) nonfixed pulmonary infiltrates and 6) biopsy evidence of extravascular eosinophils in the skin, the nerves, or the lungs. CSS has a good prognosis with systemic steroid therapy. The 5 year survival is approximately 70%. We experienced a 66-year-old man who presented with cough, sputum, edema and numbness in both legs. He presented with all of the 6 CSS criteria. A nerve and muscle biopsy confirmed the diagnosis. Here, we report this case with a review of the relevant literatures.

저자들은 기침, 객담, 그리고 양측 하지의 부종과 저린감을 주소로 내원한 환자를 신경과 근육의 조직 검사를 시행하여, 폐장 및 신경근계를 침범한 Churg-Strauss 증후군으로 확진하여 스테로이드로 성공적으로 치료한 1 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.